Miz-1 Activators
Miz-1 (Myc-interacting zinc finger protein 1) is a transcription factor that plays a significant role in the regulation of cell cycle progression and apoptosis by controlling the expression of various target genes, including those involved in cell growth and differentiation. Characterized by its ability to bind DNA through multiple zinc finger domains, Miz-1 specifically recognizes and binds to initiator elements and GC-rich sequences within the promoters of its target genes. This binding facilitates the recruitment of other transcription factors and co-regulators, thereby modulating the transcriptional activity of genes critical for cellular homeostasis. Notably, Miz-1 can function both as a transcriptional activator and repressor, depending on its interaction with other cellular proteins, such as Myc, which can alter its ability to activate gene expression. The dual role of Miz-1 underscores its importance in maintaining the balance between cell proliferation and growth arrest, highlighting its potential impact on the development of cancer and other diseases associated with dysregulated cell cycle control.
The activation of Miz-1 is a complex process that involves several regulatory mechanisms, ensuring its proper function and specificity in gene regulation. Post-translational modifications, such as phosphorylation and acetylation, play crucial roles in modulating the activity, stability, and localization of Miz-1, affecting its interaction with DNA and other proteins. For instance, phosphorylation by specific kinases can enhance Miz-1's ability to bind DNA or alter its affinity for other transcriptional regulators, thereby influencing its transcriptional activity. Furthermore, the interaction of Miz-1 with co-factors, including histone modifiers and chromatin remodelers, is essential for its ability to effectively activate or repress the transcription of target genes. These interactions not only facilitate the recruitment of Miz-1 to specific genomic loci but also enable the formation of transcriptionally active or repressive complexes, thereby dictating the outcome of Miz-1-mediated gene expression.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
10058-F4 | 403811-55-2 | sc-213577 sc-213577B sc-213577A sc-213577C | 5 mg 10 mg 25 mg 50 mg | $81.00 $134.00 $241.00 $426.00 | 9 | |
A small molecule that inhibits the interaction between c-Myc and Miz-1. 10058-F4 indirectly activates Miz-1 by preventing the formation of the c-Myc-Miz-1 complex, which typically represses Miz-1 transcriptional activities. Inhibition of the c-Myc-Miz-1 interaction leads to increased availability of Miz-1 for its target genes, promoting Miz-1-mediated transcriptional regulation. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
A selective ROCK inhibitor that indirectly activates Miz-1. Thiazovivin impacts the RhoA-ROCK pathway, leading to alterations in cellular signaling. Indirectly, Thiazovivin may modulate Miz-1 by influencing downstream effectors of the RhoA-ROCK pathway, potentially affecting Miz-1 expression or activity. | ||||||
PRIMA-1MET | 5291-32-7 | sc-361295 sc-361295A | 10 mg 25 mg | $153.00 $325.00 | 5 | |
PRIMA-1 (PRIMA-1Met) restores mutant p53 function, indirectly influencing Miz-1. APR-246 activates wild-type p53 and certain mutant forms, leading to increased levels of p53-Miz-1 complexes. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A natural compound with anti-inflammatory properties that may indirectly activate Miz-1. Curcumin impacts various signaling pathways, including NF-κB and Wnt. Indirectly, Curcumin may modulate Miz-1 by influencing these pathways, potentially affecting Miz-1 expression or activity. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $74.00 $243.00 $731.00 $2572.00 $21848.00 | 53 | |
An antibiotic that inhibits transcription and may indirectly activate Miz-1. Actinomycin D impacts RNA synthesis, leading to alterations in gene expression. The indirect activation of Miz-1 by Actinomycin D may involve changes in the transcriptional regulation of Miz-1 target genes, influencing Miz-1-mediated transcriptional activities. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
A histone deacetylase inhibitor that indirectly activates Miz-1. SAHA affects the acetylation status of histones, leading to changes in chromatin structure and gene expression. The indirect activation of Miz-1 by SAHA may involve alterations in the epigenetic regulation of Miz-1 target genes, influencing Miz-1-mediated transcriptional activities. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
A pan-CDK inhibitor that may indirectly activate Miz-1. Flavopiridol inhibits CDKs, potentially leading to alterations in cellular signaling. Indirectly, Flavopiridol may modulate Miz-1 by influencing downstream effectors of CDKs, potentially affecting Miz-1 expression or activity. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
A selective inhibitor of the histone acetyltransferase p300 that may indirectly activate Miz-1. C646 impacts the acetylation status of histones, leading to changes in chromatin structure and gene expression. The indirect activation of Miz-1 by C646 may involve alterations in the epigenetic regulation of Miz-1 target genes, influencing Miz-1-mediated transcriptional activities. | ||||||