4.1R Antibody (B-11): sc-166759

4.1R Antibody (B-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects 4.1R of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-4.1R antibody (B-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. 4.1R plays a crucial role in maintaining the structural integrity and mechanical properties of erythrocyte membranes, which is vital for proper red blood cell function and overall circulatory health. 4.1R belongs to the 4.1 gene family, which encodes a group of multifunctional cytoskeletal proteins predominantly expressed in the nervous system, including 4.1G, 4.1N, and 4.1B. The unique distribution of 4.1R and 4.1G in the cerebellum suggests their involvement in modulating the mechanical properties of neuronal cell membranes by facilitating the association of fodrin and actin. 4.1N and 4.1B are strongly expressed in the brain, with anti-4.1N antibodies detecting multiple forms enriched in postsynaptic density preparations, highlighting the diverse roles these proteins play in cellular architecture and signaling.

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4.1R Antibody (B-11) References:

1. Type II brain 4.1 (4.1B/KIAA0987), a member of the protein 4.1 family, is localized to neuronal paranodes.  |  Ohara, R., et al. 2000. Brain Res Mol Brain Res. 85: 41-52. PMID: 11146105
2. Protein 4.1 in forebrain postsynaptic density preparations: enrichment of 4.1 gene products and detection of 4.1R binding proteins.  |  Scott, C., et al. 2001. Eur J Biochem. 268: 1084-94. PMID: 11179975
3. Protein 4.1, a multifunctional protein of the erythrocyte membrane skeleton: structure and functions in erythrocytes and nonerythroid cells.  |  Takakuwa, Y. 2000. Int J Hematol. 72: 298-309. PMID: 11185985
4. The prototypical 4.1R-10-kDa domain and the 4.1g-10-kDa paralog mediate fodrin-actin complex formation.  |  Kontrogianni-Konstantopoulos, A., et al. 2001. J Biol Chem. 276: 20679-87. PMID: 11274145
5. Correlation between protein 4.1R and the progression of heart failure in vivo.  |  Wei, Z., et al. 2016. Genet Mol Res. 15: PMID: 27323040
6. Protein 4.1R Influences Myogenin Protein Stability and Skeletal Muscle Differentiation.  |  Huang, SC., et al. 2016. J Biol Chem. 291: 25591-25607. PMID: 27780863
7. Cytoskeleton protein 4.1R regulates B-cell fate by modulating the canonical NF-κB pathway.  |  Liang, T., et al. 2020. Immunology. 161: 314-324. PMID: 32852059
8. Protein 4.1R negatively regulates P815 cells proliferation by inhibiting C-Kit-mediated signal transduction.  |  Ding, C., et al. 2021. Exp Cell Res. 398: 112403. PMID: 33271128
9. Protein 4.1R affects photodynamic therapy for B16 melanoma by regulating the transport of 5-aminolevulinic acid.  |  Li, B., et al. 2021. Exp Cell Res. 399: 112465. PMID: 33385415
10. Protein 4.1R regulates M1 macrophages polarization via glycolysis, alleviating sepsis-induced liver injury in mice.  |  Sang, SY., et al. 2024. Int Immunopharmacol. 128: 111546. PMID: 38237224
11. Cytoskeletal Protein 4.1R in Health and Diseases.  |  Liu, J., et al. 2024. Biomolecules. 14: PMID: 38397451
12. Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human.  |  Peters, LL., et al. 1998. Genomics. 54: 348-50. PMID: 9828140

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-4.1R Antibody (B-11) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-4.1R Antibody (B-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

4.1R Antibody (B-11) Specifications

Alternate Product Name: 4.1R

Product Clone Name: B-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 650-665

Epitope Target: 4.1R

Epitope Species: human

Product Reactivity/Detection: 4.1R

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for 4.1R Antibody (B-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin