Molecular structure of Amsacrine hydrochloride, CAS Number: 54301-15-4
Amsacrine hydrochloride (CAS 54301-15-4)
Alternate Names:
4-(9-Acridinylamino)-N-(methanesulfonyl)-m-anisidine hydrochloride; m-AMSA
Application:
Amsacrine hydrochloride is an inhibitor of DNA topoisomerase II
CAS Number:
54301-15-4
Purity:
≥98%
Molecular Weight:
429.92
Molecular Formula:
C21H19N3O3S•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Inhibits DNA topoisomerase II.
Amsacrine hydrochloride (CAS 54301-15-4) References
Davey, R.A., et al., The potential of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide to circumvent three multidrug-resistance phenotypes in vitro. Cancer Chemother. Pharmacol. 39, 424-430, (1997) Nelson, E.M., et al., Mechanism of antitumor drug action: poisoning of mammalian DNA topoisomerase II on DNA by 4'-(9-acridinylamino)-methanesulfon-m-anisidide. Proc. Natl. Acad. Sci. USA 81, 1361-1365, (1984) Ferguson, L.R., , Application of fluorescence in situ hybridization to study the relationship between cytotoxicity, chromosome aberrations, and changes in chromosome number after treatment with the topoisomerase II inhibitor amsacrine. Environ. Mol. Mutagen. 27, 255, (1996) Mosesso, P., et al., Induction of chromosomal aberrations (unstable and stable) by inhibitors of topoisomerase II, m-AMSA and VP16, using conventional Giemsa staining and chromosome painting techniques. Mutagenesis 13, 39-43, (1998) Del Bino, G., et al., The concentration-dependent diversity of effects of DNA topoisomerase I and II inhibitors on the cell cycle of HL-60 cells. Exp. Cell Res. 195, 485-491, (1991) Negri, C., et al., Induction of apoptotic cell death by DNA topoisomerase II inhibitors. Biochimie 77, 893-899, (1995)Inhibitor of:
4930547C10Rik, AI481877, Borealin, C6orf167, CENP-L, DDX10, DDX19B, DDX42, DDX52, DFF-45, DNA pol 4, ds DNA Marker, ENSMUSG00000073257, FIGNL2, GEN1, hCAP-H, Hfm1, HTH, Mad 4, MsrB3, Ncapg, Nop5, OBFC2B, OFCC1, PIF1, PMS2, Rec8, RPA40, SNM1A, SSBP2, SWAP, THAP9, Topo II, Topo IIIβ, UIMC1, and ZNF154.Activator of:
4930547C10Rik, ALKBH2, AROS-29, TDP2, Top1, and Top3.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Amsacrine hydrochloride, 10 mg | sc-214540 | 10 mg | $232.00 |