Butyric acid-d8 (CAS 202468-80-2)
QUICK LINKS
Butyric acid-d8, known as deuterated butyric acid, is a chemically stable isotope-labeled form of butyric acid, a short-chain fatty acid produced in the human body by the gut microbiota during the fermentation of dietary fibers. This compound has been a focus of research, particularly as a tracer in metabolic studies which aim to trace the pathways of butyrate within the human system. It is employed in the exploration of how butyrate is absorbed, distributed, metabolized, and ultimately excreted. The compound operates through several mechanisms such as inhibiting histone deacetylases (HDACs), which play a role in gene expression and can induce the process of cell death in certain cell types. It also interacts with the immune system, influencing immune cells and cytokines.
Butyric acid-d8 (CAS 202468-80-2) References
- GC-MS Analysis of Short-Chain Fatty Acids in Feces, Cecum Content, and Blood Samples. | Hoving, LR., et al. 2018. Methods Mol Biol. 1730: 247-256. PMID: 29363078
- Microbiota-derived short chain fatty acids modulate microglia and promote Aβ plaque deposition. | Colombo, AV., et al. 2021. Elife. 10: PMID: 33845942
- GPR120 prevents colorectal adenocarcinoma progression by sustaining the mucosal barrier integrity. | Rubbino, F., et al. 2022. Sci Rep. 12: 381. PMID: 35013389
- Dietary butyrate ameliorates metabolic health associated with selective proliferation of gut Lachnospiraceae bacterium 28-4. | Li, Z., et al. 2023. JCI Insight. 8: PMID: 36810253
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Butyric acid-d8, 5 g | sc-300313 | 5 g | $754.00 |