CD79A Antibody (JCB117): sc-53209
- CD79A Antibody (JCB117) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 202-216 of CD79A of human origin
- recommended for detection of CD79A of mouse, rat and human origin by WB, IP, IF and IHC(P); also reactive with additional species, including porcine
- See CD79A (HM47): sc-20064 for CD79A antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for CD79A Antibody (JCB117) for WB and IHC(P) applications. These reagents are now offered in bundles with CD79A Antibody (JCB117) (see ordering information below).
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CD79A Antibody (JCB117) is a mouse monoclonal IgG1 antibody that detects CD79A in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. CD79A, also known as MB-1, is a critical component of the B cell antigen receptor complex, functioning alongside CD79B to facilitate signaling necessary for B cell activation and development. CD79A monoclonal antibody (JCB117) recognizes a protein essential for immune response, helping initiate signaling cascades upon antigen binding, which drives B cell proliferation and differentiation. The cytoplasmic tail of CD79A contains an immuno-receptor tyrosine-based activation motif (ITAM) that is crucial for recruiting and activating tyrosine kinases, thereby propagating the signal that leads to B cell activation. This signaling enables B cells to produce antibodies and mount an effective defense against pathogens. Anti-CD79A antibody (JCB117) serves as an invaluable tool for researchers studying B cell biology and mechanisms underlying immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
CD79A Antibody (JCB117) References:
- Mutations in Igalpha (CD79a) result in a complete block in B-cell development. | Minegishi, Y., et al. 1999. J Clin Invest. 104: 1115-21. PMID: 10525050
- Aberrant expression of CD7, CD56, and CD79a antigens in acute myeloid leukemias. | Cruse, JM., et al. 2005. Exp Mol Pathol. 79: 39-41. PMID: 16005710
- Frequent downregulation or loss of CD79a expression in plasma cell myelomas: potential clue for diagnosis. | Tanaka, T., et al. 2009. Pathol Int. 59: 804-8. PMID: 19883431
- Mutations of CD79A, CD79B and EZH2 genes in immunodeficiency-related non-Hodgkin lymphomas. | Capello, D., et al. 2011. Br J Haematol. 152: 777-80. PMID: 21275949
- Overexpression of immunoglobulin (CD79a) binding protein1 (IGBP-1) in small lung adenocarcinomas and its clinicopathological significance. | Sakashita, S., et al. 2011. Pathol Int. 61: 130-7. PMID: 21355954
- Synovial infiltration with CD79a-positive B cells, but not other B cell lineage markers, correlates with joint destruction in rheumatoid arthritis. | Mo, YQ., et al. 2011. J Rheumatol. 38: 2301-8. PMID: 22002013
- Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. | O'Neill, SK., et al. 2011. Immunity. 35: 746-56. PMID: 22078222
- Expression of the B-cell receptor component CD79a on immature myeloid cells contributes to their tumor promoting effects. | Luger, D., et al. 2013. PLoS One. 8: e76115. PMID: 24146823
- Immunophenotypic challenges in diagnosis of CD79a negativity in a patient with B acute lymphoblastic leukemia harboring intrachromosomal amplification of chromosome 21: a case report. | Berhili, A., et al. 2021. J Med Case Rep. 15: 531. PMID: 34706776
- Differential expression of B29 (CD79b) and mb-1 (CD79a) proteins in acute lymphoblastic leukaemia. | Astsaturov, IA., et al. 1996. Leukemia. 10: 769-73. PMID: 8656670
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CD79A Antibody (JCB117) | sc-53209 | 200 µg/ml | $316.00 | |||
CD79A Antibody (JCB117): m-IgG Fc BP-HRP Bundle | sc-536908 | 200 µg Ab; 10 µg BP | $354.00 | |||
CD79A Antibody (JCB117): m-IgGκ BP-HRP Bundle | sc-534081 | 200 µg Ab; 40 µg BP | $354.00 | |||
CD79A Antibody (JCB117): m-IgG1 BP-HRP Bundle | sc-544892 | 200 µg Ab; 20 µg BP | $354.00 |