Molecular structure of CID 755673, CAS Number: 521937-07-5
CID 755673 (CAS 521937-07-5)
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Application:
CID 755673 is a selective PKC, PKD, Plk, and HSP 27 inhibitor
CAS Number:
521937-07-5
Purity:
≥98%
Molecular Weight:
217.22
Molecular Formula:
C12H11NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
CID 755673 is a selective and potent protein kinase D1-D3, PKC, CAK, PLK1 and CAMKIIalpha inhibitor. CID 755673 has been reported to inhibit PKD-mediated protein transport and inhibit proliferation, migration and invasion of prostate cancer cell lines. In SH-SY5Y human neuroblastoma cells, small heat shock protein 27 (HSP27) Ser-82 phosphorylation induced by phorbol-12,13-dibutyrate (PDB) was completely reversed by CID 755673.
CID 755673 (CAS 521937-07-5) References
- Potent and selective disruption of protein kinase D functionality by a benzoxoloazepinolone. | Sharlow, ER., et al. 2008. J Biol Chem. 283: 33516-26. PMID: 18829454
- Multiple protein kinases determine the phosphorylated state of the small heat shock protein, HSP27, in SH-SY5Y neuroblastoma cells. | Dokas, LA., et al. 2011. Neuropharmacology. 61: 12-24. PMID: 21338617
- Lysophosphatidic acid suppresses endothelial cell CD36 expression and promotes angiogenesis via a PKD-1-dependent signaling pathway. | Ren, B., et al. 2011. Blood. 117: 6036-45. PMID: 21441463
- Receptor-independent protein kinase C alpha (PKCalpha) signaling by calpain-generated free catalytic domains induces HDAC5 nuclear export and regulates cardiac transcription. | Zhang, Y., et al. 2011. J Biol Chem. 286: 26943-51. PMID: 21642422
- Discovery of diverse small molecule chemotypes with cell-based PKD1 inhibitory activity. | Sharlow, ER., et al. 2011. PLoS One. 6: e25134. PMID: 21998636
- The BAR domain protein Arfaptin-1 controls secretory granule biogenesis at the trans-Golgi network. | Gehart, H., et al. 2012. Dev Cell. 23: 756-68. PMID: 22981988
- PKD controls mitotic Golgi complex fragmentation through a Raf-MEK1 pathway. | Kienzle, C., et al. 2013. Mol Biol Cell. 24: 222-33. PMID: 23242995
- The p38 MAPK-regulated PKD1/CREB/Bcl-2 pathway contributes to selenite-induced colorectal cancer cell apoptosis in vitro and in vivo. | Hui, K., et al. 2014. Cancer Lett. 354: 189-99. PMID: 25128071
- Protein kinase d inhibitors uncouple phosphorylation from activity by promoting agonist-dependent activation loop phosphorylation. | Kunkel, MT. and Newton, AC. 2015. Chem Biol. 22: 98-106. PMID: 25556943
- Molecular cloning, epigenetic regulation, and functional characterization of Prkd1 gene promoter in dopaminergic cell culture models of Parkinson's disease. | Ay, M., et al. 2015. J Neurochem. 135: 402-15. PMID: 26230914
- Regulation of membrane KCNQ1/KCNE1 channel density by sphingomyelin synthase 1. | Wu, M., et al. 2016. Am J Physiol Cell Physiol. 311: C15-23. PMID: 27194473
- Biological or pharmacological activation of protein kinase C alpha constrains hepatitis E virus replication. | Wang, W., et al. 2017. Antiviral Res. 140: 1-12. PMID: 28077314
- Phosphine-mediated sequential annulations of allenyl ketone and isocyanide: a bicyclization strategy to access a furan-fused eight-membered ring and a spirocycle. | Xue, B., et al. 2019. Chem Commun (Camb). 55: 12180-12183. PMID: 31544180
- Protein kinase D, ubiquitin and proteasome pathways are involved in adenosine receptor-stimulated NR4A expression in myeloid cells. | Giffney, HE., et al. 2021. Biochem Biophys Res Commun. 555: 19-25. PMID: 33812054
- Perfluorooctane Sulfonic Acid Disrupts Protective Tight Junction Proteins via Protein Kinase D in Airway Epithelial Cells. | Lucas, JH., et al. 2022. Toxicol Sci. 190: 215-226. PMID: 36106993
Inhibitor of:
casein kinase I delta, Cdk2, cytohesin-2, HSP 27, MAPKAPK-2, PKC, PKC ν, PKD, Plk, PRAK, and Ser/Thr Protein Kinase.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
CID 755673, 10 mg | sc-205246 | 10 mg | $203.00 |