CyPB Antibody (k2E2): sc-130626

CyPB Antibody (k2E2) is a mouse monoclonal IgG1 antibody that detects CyPB protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-CyPB antibody (k2E2) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Cyclophilin B (CyPB) plays a crucial role in various cellular processes, particularly in the endoplasmic reticulum, where CyPB assists in protein folding and trafficking. The presence of specific N- and C-terminal extensions in CyPB distinguishes CyPB from other cyclophilins, such as CyPA, and a unique signal sequence facilitates translocation into the endoplasmic reticulum. Once secreted into biological fluids like blood and milk, CyPB interacts with specific receptors on human lymphoblastic cell lines and peripheral blood lymphocytes, highlighting CyPB′s significance in immune responses. Additionally, CyPB is involved in the modulation of T cell activation and has been implicated in various diseases, making CyPB a valuable target for therapeutic interventions. With CyPB′s ability to form complexes with immunosuppressants like cyclosporin A, CyPB is essential for understanding the mechanisms of immune regulation and viral replication, particularly in the context of HIV-1, where CyPB is incorporated into the viral structure, underscoring CyPB′s importance in both basic and applied biomedical research.

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CyPB Antibody (k2E2) References:

1. Maturation-induced conformational changes of HIV-1 capsid protein and identification of two high affinity sites for cyclophilins in the C-terminal domain.  |  Endrich, MM., et al. 1999. J Biol Chem. 274: 5326-32. PMID: 10026140
2. Two cyclophilin A homologs with shared and distinct functions important for growth and virulence of Cryptococcus neoformans.  |  Wang, P., et al. 2001. EMBO Rep. 2: 511-8. PMID: 11415984
3. Effects of altered cyclophilin A expression on growth and differentiation of human and mouse neuronal cells.  |  Nahreini, P., et al. 2001. Cell Mol Neurobiol. 21: 65-79. PMID: 11440199
4. s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.  |  Arber, S., et al. 1992. J Cell Biol. 116: 113-25. PMID: 1530944
5. An endoplasmic reticulum-specific cyclophilin.  |  Hasel, KW., et al. 1991. Mol Cell Biol. 11: 3484-91. PMID: 1710767
6. In situ detection of cyclosporin A: evidence for nuclear localization of cyclosporine and cyclophilins.  |  Le Hir, M., et al. 1995. Lab Invest. 73: 727-33. PMID: 7474947
7. X-ray structure of a decameric cyclophilin-cyclosporin crystal complex.  |  Pflügl, G., et al. 1993. Nature. 361: 91-4. PMID: 8421501
8. Evidence that human milk isolated cyclophilin B corresponds to a truncated form.  |  Mariller, C., et al. 1996. Biochim Biophys Acta. 1293: 31-8. PMID: 8652625
9. Involvement of the N-terminal part of cyclophilin B in the interaction with specific Jurkat T-cell binding sites.  |  Mariller, C., et al. 1996. Biochem J. 317 (Pt 2): 571-6. PMID: 8713087
10. Crystal structure of cyclophilin A complexed with a binding site peptide from the HIV-1 capsid protein.  |  Vajdos, FF., et al. 1997. Protein Sci. 6: 2297-307. PMID: 9385632

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CyPB Antibody (k2E2) has 11 citations in a variety of scientific publications.

Primary antibodies like Anti-CyPB Antibody (k2E2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CyPB Antibody (k2E2) Specifications

Alternate Product Name: CyPB

Product Clone Name: k2E2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids: 26-216

Epitope Target: CyPB

Epitope Species: human

Product Reactivity/Detection: CyPB

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% glycerol

Research Citations: 11 citations in various scientific publications

Available Conjugates/Forms for CyPB Antibody (k2E2): N/A