Dimethyl 3,3′-dithiopropionimidate dihydrochloride (CAS 38285-78-8)
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Dimethyl 3,3′-dithiopropionimidate dihydrochloride is a thiol-cleavable, homobifunctional amine-reactive crosslinker. It may act to react with primary amines in the pH range 7.0-10.0 to form amidine bonds.Note that the amidine linkage preserves original primary amine (+)charge. It incorporates an 8 atom spacer arm. Dimethyl 3,3′-dithiopropionimidate dihydrochloride is a notable chemical compound frequently utilized in protein research as a cross-linking agent. It′s a water-soluble crystalline material known for enhancing the stability of protein structures and improving their resistance to enzymatic breakdown. Its primary strength lies in its ability to form enduring cross-links between multiple proteins. This makes it indispensable in various scientific experiments, especially in protein crystallography for fortifying protein configurations and in biomaterials science.
Dimethyl 3,3′-dithiopropionimidate dihydrochloride (CAS 38285-78-8) References
- Protein complexes in the archaeon Methanothermobacter thermautotrophicus analyzed by blue native/SDS-PAGE and mass spectrometry. | Farhoud, MH., et al. 2005. Mol Cell Proteomics. 4: 1653-63. PMID: 16037073
- The development and characterization of a glutathione-sensitive cross-linked polyethylenimine gene vector. | Wang, Y., et al. 2006. Biomaterials. 27: 5292-8. PMID: 16806454
- Apoptotic cells induce Mer tyrosine kinase-dependent blockade of NF-kappaB activation in dendritic cells. | Sen, P., et al. 2007. Blood. 109: 653-60. PMID: 17008547
- A review of stimuli-responsive nanocarriers for drug and gene delivery. | Ganta, S., et al. 2008. J Control Release. 126: 187-204. PMID: 18261822
- Templated synthesis of single-component polymer capsules and their application in drug delivery. | Wang, Y., et al. 2008. Nano Lett. 8: 1741-5. PMID: 18489168
- The effects of dimethyl 3,3'-dithiobispropionimidate di-hydrochloride cross-linking of collagen and gelatin coating on porous spherical biphasic calcium phosphate granules. | Kim, YH., et al. 2014. J Biomater Appl. 29: 386-98. PMID: 24733775
- Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast. | Sun, LT., et al. 2014. Dev Biol. 392: 182-92. PMID: 24929238
- The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency. | Bertero, A., et al. 2018. Nature. 555: 256-259. PMID: 29489750
- Glutathione Bioresponsive Cyclodextrin Nanosponges. | Trotta, F., et al. 2016. Chempluschem. 81: 439-443. PMID: 31968779
- Redox-responsive polyethyleneimine/tetrahedron DNA/doxorubicin nanocomplexes for deep cell/tissue penetration to overcome multidrug resistance. | Yan, J., et al. 2021. J Control Release. 329: 36-49. PMID: 33259850
- Synergistic Effect of Uroguanylin and D1 Dopamine Receptors on Sodium Excretion in Hypertension. | Zeng, C., et al. 2022. J Am Heart Assoc. 11: e022827. PMID: 35229618
- Enhanced stability of complex coacervate core micelles following different core-crosslinking strategies. | Kembaren, R., et al. 2022. Soft Matter. 18: 3052-3062. PMID: 35363245
- Neural Stem Cells as Carriers of Nucleoside-Conjugated Nanogels: A New Approach toward Cell-Mediated Delivery. | Morgenroth, A., et al. 2023. ACS Appl Mater Interfaces. 15: 21792-21803. PMID: 37127284
- A Comparison of Thiolated and Disulfide-Crosslinked Polyethylenimine for Nonviral Gene Delivery | Latha Aravindan, Katrina A. Bicknell, Gavin Brooks, Vitaliy V. Khutoryanskiy, Adrian C. Williams. 2013. 13: 1163-1173.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Dimethyl 3,3′-dithiopropionimidate dihydrochloride, 100 mg | sc-252733 | 100 mg | $86.00 |