JMJD8 Antibody (H-4): sc-515520
- JMJD8 Antibody (H-4) is a mouse monoclonal IgG2b κ JMJD8 antibody, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 192-216 within an internal region of JMJD8 of human origin
- JMJD8 Antibody (H-4) is recommended for detection of JMJD8 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-JMJD8 Antibody (H-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JMJD8 Antibody (H-4) for WB applications. These reagents are now offered in bundles with JMJD8 Antibody (H-4) (see ordering information below).
JMJD8 Antibody (H-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects JMJD8 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-JMJD8 antibody (H-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. JMJD8, also known as Jumonji domain-containing protein 8, consists of 334 amino acids and features a single Jumonji domain, which is crucial for its role as a histone demethylase. This enzymatic activity is vital for the regulation of gene expression, as JMJD8 modifies histones to influence chromatin structure and accessibility, thereby impacting cellular processes such as differentiation and development. JMJD8 is located on human chromosome 16, a region associated with various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, highlighting JMJD8′s importance in maintaining normal cellular function and potential implications in disease. Using JMJD8 monoclonal antibody (H-4) enables researchers to gain insights into the regulatory mechanisms of gene expression and the role of histone modifications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
JMJD8 Antibody (H-4) References:
- Homozygosity mapping of giant axonal neuropathy gene to chromosome 16q24.1. | Ben Hamida, C., et al. 1997. Neurogenetics. 1: 129-33. PMID: 10732815
- Novel quantitative trait loci controlling development of experimental autoimmune encephalomyelitis and proportion of lymphocyte subpopulations. | Karlsson, J., et al. 2003. J Immunol. 170: 1019-26. PMID: 12517969
- Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus. | Forabosco, P., et al. 2006. Genes Immun. 7: 609-14. PMID: 16971955
- Giant axonal neuropathy. | Yang, Y., et al. 2007. Cell Mol Life Sci. 64: 601-9. PMID: 17256086
- Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN). | Koop, O., et al. 2007. Neuromuscul Disord. 17: 624-30. PMID: 17587580
- The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. | Tattoli, I., et al. 2007. Semin Immunopathol. 29: 289-301. PMID: 17690884
- Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene. | King, K., et al. 2007. Genomics. 90: 493-501. PMID: 17719742
- High frequency of mosaic CREBBP deletions in Rubinstein-Taybi syndrome patients and mapping of somatic and germ-line breakpoints. | Gervasini, C., et al. 2007. Genomics. 90: 567-73. PMID: 17855048
- Nod-like receptors in innate immunity and inflammatory diseases. | Carneiro, LA., et al. 2007. Ann Med. 39: 581-93. PMID: 18038361
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JMJD8 Antibody (H-4) | sc-515520 | 200 µg/ml | $316.00 | |||
JMJD8 Antibody (H-4): m-IgGκ BP-HRP Bundle | sc-525081 | 200 µg Ab, 40 µg BP | $354.00 | |||
JMJD8 Antibody (H-4): m-IgG2b BP-HRP Bundle | sc-549210 | 200 µg Ab; 10 µg BP | $354.00 | |||
JMJD8 Antibody (H-4) AC | sc-515520 AC | 500 µg/ml, 25% agarose | $416.00 | |||
JMJD8 Antibody (H-4) HRP | sc-515520 HRP | 200 µg/ml | $316.00 | |||
JMJD8 Antibody (H-4) FITC | sc-515520 FITC | 200 µg/ml | $330.00 | |||
JMJD8 Antibody (H-4) PE | sc-515520 PE | 200 µg/ml | $343.00 | |||
JMJD8 Antibody (H-4) Alexa Fluor® 488 | sc-515520 AF488 | 200 µg/ml | $357.00 | |||
JMJD8 Antibody (H-4) Alexa Fluor® 546 | sc-515520 AF546 | 200 µg/ml | $357.00 | |||
JMJD8 Antibody (H-4) Alexa Fluor® 594 | sc-515520 AF594 | 200 µg/ml | $357.00 | |||
JMJD8 Antibody (H-4) Alexa Fluor® 647 | sc-515520 AF647 | 200 µg/ml | $357.00 | |||
JMJD8 Antibody (H-4) Alexa Fluor® 680 | sc-515520 AF680 | 200 µg/ml | $357.00 | |||
JMJD8 Antibody (H-4) Alexa Fluor® 790 | sc-515520 AF790 | 200 µg/ml | $357.00 | |||
JMJD8 (H-4) Neutralizing Peptide | sc-515520 P | 100 µg/0.5 ml | $68.00 |