LRG1 Antibody (C-4): sc-390920

LRG1 Antibody (C-4) is a mouse monoclonal IgG3 kappa light chain antibody that detects LRG1 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LRG1 Antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LRG1, or leucine-rich alpha-2-glycoprotein, is a 347 amino acid secreted protein characterized by the presence of eight leucine-rich repeats and one LRRCT domain, which are crucial for mediating protein-protein interactions, signal transduction, and cell adhesion. LRG1 is primarily found in plasma and is notably expressed during granulocyte differentiation, highlighting LRG1′s importance in immune response and inflammation. The gene encoding LRG1 is located on human chromosome 19p13.3, a region known for housing numerous immunoglobulin superfamily members, which play vital roles in immune regulation. Understanding LRG1 function and interactions can provide insights into various biological processes and potential therapeutic targets, making anti-LRG1 antibody (C-4) an essential tool for researchers studying immune responses and related pathways.

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LRG1 Antibody (C-4) References:

1. Molecular characterization and expression analysis of leucine-rich alpha2-glycoprotein, a novel marker of granulocytic differentiation.  |  O'Donnell, LC., et al. 2002. J Leukoc Biol. 72: 478-85. PMID: 12223515
2. Up-regulation of the expression of leucine-rich alpha(2)-glycoprotein in hepatocytes by the mediators of acute-phase response.  |  Shirai, R., et al. 2009. Biochem Biophys Res Commun. 382: 776-9. PMID: 19324010
3. Cytochrome c-induced lymphocyte death from the outside in: inhibition by serum leucine-rich alpha-2-glycoprotein-1.  |  Codina, R., et al. 2010. Apoptosis. 15: 139-52. PMID: 19851871
4. Autologous extracellular cytochrome c is an endogenous ligand for leucine-rich alpha2-glycoprotein and beta-type phospholipase A2 inhibitor.  |  Shirai, R., et al. 2010. J Biol Chem. 285: 21607-14. PMID: 20442399
5. Proteomic analysis of coronary sinus serum reveals leucine-rich α2-glycoprotein as a novel biomarker of ventricular dysfunction and heart failure.  |  Watson, CJ., et al. 2011. Circ Heart Fail. 4: 188-97. PMID: 21282491
6. Proteomic identification of exosomal LRG1: a potential urinary biomarker for detecting NSCLC.  |  Li, Y., et al. 2011. Electrophoresis. 32: 1976-83. PMID: 21557262
7. LRG1 promotes hypoxia-induced cardiomyocyte apoptosis and autophagy by regulating hypoxia-inducible factor-1α.  |  Feng, J., et al. 2021. Bioengineered. 12: 8897-8907. PMID: 34643170
8. LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.  |  He, S., et al. 2021. J Clin Invest. 131: PMID: 34730111
9. Single-cell RNA sequencing unveils Lrg1's role in cerebral ischemia‒reperfusion injury by modulating various cells.  |  Ruan, Z., et al. 2023. J Neuroinflammation. 20: 285. PMID: 38037097
10. Periodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serum.  |  Takahashi, N., et al. 1985. Proc Natl Acad Sci U S A. 82: 1906-10. PMID: 3856868
11. LRG1 promotes atherosclerosis by inducing macrophage M1-like polarization.  |  Wang, J., et al. 2024. Proc Natl Acad Sci U S A. 121: e2405845121. PMID: 39178231
12. [Isolation and characterization of an unknown, leucine-rich 3.1-S-alpha2-glycoprotein from human serum (author's transl)].  |  Haupt, H. and Baudner, S. 1977. Hoppe Seylers Z Physiol Chem. 358: 639-46. PMID: 69600

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LRG1 Antibody (C-4) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-LRG1 Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LRG1 Antibody (C-4) Specifications

Alternate Product Name: LRG1

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₃ kappa light chain

Amino Acids: 264-291

Epitope Target: LRG1

Epitope Species: mouse

Product Reactivity/Detection: LRG1

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₃ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for LRG1 Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin