MAGP-1 Antibody (E-8): sc-271518

MAGP-1 Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects MAGP-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAGP-1, or microfibril-associated glycoprotein 1, plays a crucial role in the formation and stabilization of elastic fibers, which are essential for the resilience and elasticity of various connective tissues. MAGP-1 is primarily located in the extracellular matrix, where MAGP-1 interacts with other key components such as fibrillin and elastin, forming a complex that is vital for maintaining the structural integrity of tissues. MAGP-1′s presence in the extracellular space is significant because MAGP-1 not only contributes to the assembly of elastic fibers but also participates in cellular signaling pathways that influence tissue repair and regeneration. Additionally, MAGP-1 undergoes post-translational modifications, including O-glycosylation, which can affect stability and interactions with other proteins, further underscoring MAGP-1′s importance in vascular development and tissue homeostasis. Anti-MAGP-1 antibody (E-8) is an invaluable tool for researchers studying the dynamics of elastic fiber formation and the molecular mechanisms underlying connective tissue disorders.

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MAGP-1 Antibody (E-8) References:

1. Expression of microfibril-associated glycoprotein-1 (MAGP-1) in human epidermal keratinocytes.  |  Fujimoto, N., et al. 2000. Arch Dermatol Res. 292: 21-6. PMID: 10664011
2. Posttranslational modifications of microfibril associated glycoprotein-1 (MAGP-1).  |  Trask, BC., et al. 2001. Biochemistry. 40: 4372-80. PMID: 11284693
3. Protein interaction studies of MAGP-1 with tropoelastin and fibrillin-1.  |  Jensen, SA., et al. 2001. J Biol Chem. 276: 39661-6. PMID: 11481325
4. Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation.  |  Miyamoto, A., et al. 2006. J Biol Chem. 281: 10089-97. PMID: 16492672
5. Microfibril-associated glycoproteins MAGP-1 and MAGP-2 in disease.  |  Craft, CS., et al. 2018. Matrix Biol. 71-72: 100-111. PMID: 29524629
6. MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations.  |  Villain, G., et al. 2018. FEBS J. 285: 4394-4412. PMID: 30338930
7. Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1.  |  Broekelmann, TJ., et al. 2020. J Biol Chem. 295: 2687-2697. PMID: 31988245
8. Microfibril-associated glycoprotein-1 (MAGP-1) is specifically located on the beads of the beaded-filament structure for fibrillin-containing microfibrils as visualized by the rotary shadowing technique.  |  Henderson, M., et al. 1996. J Histochem Cytochem. 44: 1389-97. PMID: 8985131
9. Microfibril-associated glycoprotein-1 (MAGP-1) binds to the pepsin-resistant domain of the alpha3(VI) chain of type VI collagen.  |  Finnis, ML. and Gibson, MA. 1997. J Biol Chem. 272: 22817-23. PMID: 9278443
10. Microfibril-associated glycoprotein-2 (MAGP-2) is specifically associated with fibrillin-containing microfibrils but exhibits more restricted patterns of tissue localization and developmental expression than its structural relative MAGP-1.  |  Gibson, MA., et al. 1998. J Histochem Cytochem. 46: 871-86. PMID: 9671438

The preferred MAGP-1 antibody is MAGP-1 Antibody (G-7): sc-166075.