MEF-2C Antibody (G-5): sc-518152

MEF-2C Antibody (G-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects MEF-2C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MEF-2C (G-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The myocyte enhancer factor-2 (MEF-2) family, which includes MEF-2C, plays a crucial role in regulating gene expression during the development and function of T cells, neuronal cells, and muscle cells. MEF-2C monoclonal antibody (G-5) is essential for studying muscle differentiation and interactions with various myogenic regulatory factors, such as MyoD and myogenin, which are vital for the transition from mesodermal precursor cells to mature muscle fibers. The ability of MEF-2C to form homo- and heterodimers with other MEF-2 family members allows for a complex regulatory network that fine-tunes the expression of muscle-specific genes, highlighting its importance in muscle development and regeneration. Anti-MEF-2C antibody (G-5) enables researchers to gain insights into the molecular mechanisms underlying muscle differentiation and the broader implications for muscle-related diseases.

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MEF-2C Antibody (G-5) References:

1. Sequence-specific recruitment of transcriptional co-repressor Cabin1 by myocyte enhancer factor-2.  |  Han, A., et al. 2003. Nature. 422: 730-4. PMID: 12700764
2. Role of smad- and wnt-dependent pathways in embryonic cardiac development.  |  Pal, R. and Khanna, A. 2006. Stem Cells Dev. 15: 29-39. PMID: 16522160
3. Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population.  |  Gude, N., et al. 2006. Circ Res. 99: 381-8. PMID: 16840722
4. TNF-alpha regulates myogenesis and muscle regeneration by activating p38 MAPK.  |  Chen, SE., et al. 2007. Am J Physiol Cell Physiol. 292: C1660-71. PMID: 17151142
5. The p38alpha/beta mitogen-activated protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes.  |  Meissner, JD., et al. 2007. J Biol Chem. 282: 7265-75. PMID: 17210568
6. Aberrant extracellular signal-regulated kinase (ERK) 5 signaling in hippocampus of suicide subjects.  |  Dwivedi, Y., et al. 2007. Neuropsychopharmacology. 32: 2338-50. PMID: 17342168
7. The MEF2B homologue differentially expressed in mouse embryonal carcinoma cells.  |  Hidaka, K., et al. 1995. Biochem Biophys Res Commun. 213: 555-60. PMID: 7646512
8. Myocyte enhancer factor (MEF) 2C: a tissue-restricted member of the MEF-2 family of transcription factors.  |  Martin, JF., et al. 1993. Proc Natl Acad Sci U S A. 90: 5282-6. PMID: 8506376
9. Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23.  |  Hobson, GM., et al. 1995. Genomics. 29: 704-11. PMID: 8575763
10. High affinity binding of MEF-2C correlates with DNA bending.  |  Meierhans, D., et al. 1997. Nucleic Acids Res. 25: 4537-44. PMID: 9358163
11. The N-terminal methionine is a major determinant of the DNA binding specificity of MEF-2C.  |  Meierhans, D. and Allemann, RK. 1998. J Biol Chem. 273: 26052-60. PMID: 9748284
12. Regulation of the MEF2 family of transcription factors by p38.  |  Zhao, M., et al. 1999. Mol Cell Biol. 19: 21-30. PMID: 9858528

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEF-2C Antibody (G-5) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-MEF-2C Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEF-2C Antibody (G-5) Specifications

Alternate Product Name: MEF-2C

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 116-142

Epitope Target: MEF-2C

Epitope Species: human

Product Reactivity/Detection: MEF-2C

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for MEF-2C Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred p-MEF-2 antibody is p-MEF-2 Antibody (B-11): sc-377535.