MEK kinase-2 Antibody (H-9): sc-398091
- MEK kinase-2 Antibody (H-9) is a mouse monoclonal IgG2b κ MEK kinase-2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 588-611 at the C-terminus of MEK kinase-2 of mouse origin
- MEK kinase-2 Antibody (H-9) is recommended for detection of MEK kinase-2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and porcine
- Anti-MEK kinase-2 Antibody (H-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2b BP-HRP are the preferred secondary detection reagents for MEK kinase-2 Antibody (H-9) for WB applications. These reagents are now offered in bundles with MEK kinase-2 Antibody (H-9) (see ordering information below).
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MEK kinase-2 Antibody (H-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects MEK kinase-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MEK kinase-2 antibody (H-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MEK kinase-2 plays a crucial role in the mitogen-activated protein (MAP) kinase signaling cascade, which is essential for cellular responses to growth factors and other extracellular signals. Specifically, MEK kinase-2 acts as a dual-specificity kinase that phosphorylates and activates extracellular signal-regulated kinases (ERKs), which are pivotal in regulating cell proliferation, differentiation, and survival. Proper functioning of MEK kinase-2 is vital for maintaining normal cellular processes, and dysregulation has been implicated in various diseases, including cancer. Understanding the interactions and regulatory mechanisms involving MEK kinase-2 can provide insights into therapeutic targets for treating such conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MEK kinase-2 Antibody (H-9) References:
- The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. | Guan, KL. 1994. Cell Signal. 6: 581-9. PMID: 7857762
- A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. | Lange-Carter, CA., et al. 1993. Science. 260: 315-9. PMID: 8385802
- Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. | Wang, XS., et al. 1996. J Biol Chem. 271: 31607-11. PMID: 8940179
- Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. | Gerwins, P., et al. 1997. J Biol Chem. 272: 8288-95. PMID: 9079650
- Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. | Deacon, K. and Blank, JL. 1997. J Biol Chem. 272: 14489-96. PMID: 9162092
- MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. | Fanger, GR., et al. 1997. EMBO J. 16: 4961-72. PMID: 9305638
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK kinase-2 Antibody (H-9) | sc-398091 | 200 µg/ml | $316.00 | |||
MEK kinase-2 Antibody (H-9): m-IgG Fc BP-HRP Bundle | sc-526286 | 200 µg Ab; 10 µg BP | $354.00 | |||
MEK kinase-2 Antibody (H-9): m-IgG2b BP-HRP Bundle | sc-549708 | 200 µg Ab; 10 µg BP | $354.00 | |||
MEK kinase-2 Antibody (H-9) AC | sc-398091 AC | 500 µg/ml, 25% agarose | $416.00 | |||
MEK kinase-2 Antibody (H-9) HRP | sc-398091 HRP | 200 µg/ml | $316.00 | |||
MEK kinase-2 Antibody (H-9) FITC | sc-398091 FITC | 200 µg/ml | $330.00 | |||
MEK kinase-2 Antibody (H-9) PE | sc-398091 PE | 200 µg/ml | $343.00 | |||
MEK kinase-2 Antibody (H-9) Alexa Fluor® 488 | sc-398091 AF488 | 200 µg/ml | $357.00 | |||
MEK kinase-2 Antibody (H-9) Alexa Fluor® 546 | sc-398091 AF546 | 200 µg/ml | $357.00 | |||
MEK kinase-2 Antibody (H-9) Alexa Fluor® 594 | sc-398091 AF594 | 200 µg/ml | $357.00 | |||
MEK kinase-2 Antibody (H-9) Alexa Fluor® 647 | sc-398091 AF647 | 200 µg/ml | $357.00 | |||
MEK kinase-2 Antibody (H-9) Alexa Fluor® 680 | sc-398091 AF680 | 200 µg/ml | $357.00 | |||
MEK kinase-2 Antibody (H-9) Alexa Fluor® 790 | sc-398091 AF790 | 200 µg/ml | $357.00 | |||
MEK kinase-2 (H-9) Neutralizing Peptide | sc-398091 P | 100 µg/0.5 ml | $68.00 |