MEK kinase-3 Antibody (40): sc-136260
- MEK kinase-3 Antibody (40) is a mouse monoclonal IgG1 κ MEK kinase-3 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 27-135 of MEK kinase-3 of human origin
- recommended for detection of MEK kinase-3 of mouse, rat, human and canine origin by WB, IP and IF
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MEK kinase-3 Antibody (40) for WB applications. This reagent is now offered in a bundle with MEK kinase-3 Antibody (40) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MEK kinase-3 Antibody (40) is a mouse monoclonal IgG1 kappa light chain antibody that detects MEK kinase-3 protein of mouse, rat, human, and canine origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-MEK kinase-3 antibody (40) is available as non-conjugated format. MEK kinase-3 plays a crucial role in mitogen-activated protein (MAP) kinase signaling pathways, which are essential for cellular responses to various extracellular stimuli, including growth factors. Specifically, MEK kinase-3 is involved in phosphorylation and activation of downstream MAP kinases, such as ERK, JNK, and p38, which are pivotal for regulating processes like cell proliferation, differentiation, and survival. Precise regulation of these pathways is vital for maintaining normal cellular functions and preventing diseases such as cancer, where aberrant signaling can lead to uncontrolled cell growth. Additionally, MEK kinase-3 is preferentially activated by MEK kinase-3 itself, highlighting its importance in the signaling cascade. Understanding the interactions and regulatory mechanisms of MEK kinase-3 can provide insights into therapeutic targets for various diseases, making anti-MEK kinase-3 antibody (40) an invaluable tool for researchers studying these critical pathways.
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MEK kinase-3 Antibody (40) References:
- The mitogen activated protein kinase signal transduction pathway: from the cell surface to the nucleus. | Guan, KL. 1994. Cell Signal. 6: 581-9. PMID: 7857762
- A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. | Lange-Carter, CA., et al. 1993. Science. 260: 315-9. PMID: 8385802
- Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. | Wang, XS., et al. 1996. J Biol Chem. 271: 31607-11. PMID: 8940179
- Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. | Gerwins, P., et al. 1997. J Biol Chem. 272: 8288-95. PMID: 9079650
- Characterization of the mitogen-activated protein kinase kinase 4 (MKK4)/c-Jun NH2-terminal kinase 1 and MKK3/p38 pathways regulated by MEK kinases 2 and 3. MEK kinase 3 activates MKK3 but does not cause activation of p38 kinase in vivo. | Deacon, K. and Blank, JL. 1997. J Biol Chem. 272: 14489-96. PMID: 9162092
- MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. | Fanger, GR., et al. 1997. EMBO J. 16: 4961-72. PMID: 9305638
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MEK kinase-3 Antibody (40) | sc-136260 | 200 µg/ml | $316.00 | |||
MEK kinase-3 Antibody (40): m-IgGκ BP-HRP Bundle | sc-521348 | 200 µg Ab, 40 µg BP | $354.00 |