MOZ Antibody (4D8): sc-293283

MOZ Antibody (4D8) is a mouse monoclonal IgG2b kappa light chain antibody that detects MOZ protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-MOZ antibody (4D8) is available as the non-conjugated isotype antibody. MOZ protein, also known as monocytic leukemia zinc finger protein, plays a crucial role as a chromatin-associated histone acetyltransferase (HAT) essential for chromatin remodeling and transcription regulation. MOZ (4D8) monoclonal antibody facilitates the acetylation of histones, leading to a more open chromatin structure that allows transcription machinery to access DNA. MOZ protein has been implicated in acute myeloid leukemias due to involvement in variant translocations that result in the formation of MOZ fusion proteins, which can aberrantly enhance transcriptional activation through altered histone acetylation. MOZ (4D8) antibody interacts with other proteins such as MORF (MOZ-related factor) and Tip60, both sharing significant structural similarities and functional roles in transcriptional regulation. MORF possesses both HAT activity and transcriptional repression capabilities, while Tip60 is known for its role as a coactivator for various nuclear hormone receptors, further underscoring MOZ protein′s importance in cellular processes and potential implications in cancer biology.

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MOZ Antibody (4D8) References:

1. Tip60 is a nuclear hormone receptor coactivator.  |  Brady, ME., et al. 1999. J Biol Chem. 274: 17599-604. PMID: 10364196
2. Identification of a human histone acetyltransferase related to monocytic leukemia zinc finger protein.  |  Champagne, N., et al. 1999. J Biol Chem. 274: 28528-36. PMID: 10497217
3. Role of the MOZ/MLL-mediated transcriptional activation system for self-renewal in normal hematopoiesis and leukemogenesis.  |  Yokoyama, A. 2022. FEBS J. 289: 7987-8002. PMID: 34482632
4. The role of MOZ/KAT6A in hematological malignancies and advances in MOZ/KAT6A inhibitors.  |  Su, J., et al. 2021. Pharmacol Res. 174: 105930. PMID: 34626770
5. MOZ and Menin-MLL Complexes Are Complementary Regulators of Chromatin Association and Transcriptional Output in Gastrointestinal Stromal Tumor.  |  Hemming, ML., et al. 2022. Cancer Discov. 12: 1804-1823. PMID: 35499757
6. MOZ is critical for the development of MOZ/MLL fusion-induced leukemia through regulation of Hoxa9/Meis1 expression.  |  Katsumoto, T., et al. 2022. Blood Adv. 6: 5527-5537. PMID: 35947126
7. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein.  |  Borrow, J., et al. 1996. Nat Genet. 14: 33-41. PMID: 8782817
8. mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila.  |  Hilfiker, A., et al. 1997. EMBO J. 16: 2054-60. PMID: 9155031
9. Abnormalities of chromosome band 8p11 in leukemia: two clinical syndromes can be distinguished on the basis of MOZ involvement.  |  Aguiar, RC., et al. 1997. Blood. 90: 3130-5. PMID: 9376594
10. Novel substrate specificity of the histone acetyltransferase activity of HIV-1-Tat interactive protein Tip60.  |  Yamamoto, T. and Horikoshi, M. 1997. J Biol Chem. 272: 30595-8. PMID: 9388189
11. A novel fusion between MOZ and the nuclear receptor coactivator TIF2 in acute myeloid leukemia.  |  Carapeti, M., et al. 1998. Blood. 91: 3127-33. PMID: 9558366
12. Roles of histone acetyltransferases and deacetylases in gene regulation.  |  Kuo, MH. and Allis, CD. 1998. Bioessays. 20: 615-26. PMID: 9780836

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MOZ Antibody (4D8) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MOZ Antibody (4D8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MOZ Antibody (4D8) Specifications

Alternate Product Name: MOZ

Product Clone Name: 4D8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 81-179

Epitope Target: MOZ

Epitope Species: human

Product Reactivity/Detection: MOZ

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MOZ Antibody (4D8): N/A