P504S Antibody (2A10F3): sc-81710
- P504S Antibody (2A10F3) is a mouse monoclonal IgG2b λ, cited in 6 publications, provided at 200 µg/ml
- raised against amino acids 132-321 of P504S of human origin
- Anti-P504S Antibody (2A10F3) is recommended for detection of P504S of mouse, rat and human origin by WB, IP, IF and IHC(P)
- Anti-P504S Antibody (2A10F3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGλ BP-HRP are the preferred secondary detection reagents for P504S Antibody (2A10F3) for WB and IHC(P) applications. These reagents are now offered in bundles with P504S Antibody (2A10F3) (see ordering information below).
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P504S Antibody (2A10F3) is a mouse monoclonal IgG2b antibody that detects P504S in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. P504S (2A10F3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. P504S, also known as AMACR (α-methylacyl-CoA racemase), is an enzyme that plays a crucial role in the metabolism of branched-chain fatty acids and bile acid intermediates. P504S is localized in the peroxisome and mitochondrion, where P504S catalyzes the conversion of pristanoyl-CoA and C27-bile acyl-CoAs to their (S)-stereoisomers, which are essential for subsequent degradation via peroxisomal β-oxidation. Proper functioning of P504S is vital, as mutations in the gene encoding this enzyme can lead to AMACR deficiency, resulting in elevated levels of pristanic acid and associated disorders such as adult-onset sensory motor neuropathy and congenital bile acid synthesis defect type 4, characterized by intrahepatic cholestasis and neonatal jaundice. Furthermore, P504S is overexpressed in prostate cancer, highlighting P504S′s potential role in promoting cancer cell growth and making P504S a significant target for research in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
P504S Antibody (2A10F3) References:
- Alpha-methylacyl-CoA racemase/P504S overexpression in colorectal carcinoma is correlated with tumor differentiation. | Shi, X., et al. 2007. Appl Immunohistochem Mol Morphol. 15: 175-80. PMID: 17525630
- Alpha-methylacyl-CoA-racemase expression in adenocarcinoma, dysplasia and non-neoplastic epithelium of the stomach. | Lee, WA. 2006. Oncology. 71: 246-50. PMID: 17652945
- Polymorphic variants in alpha-methylacyl-CoA racemase and prostate cancer. | Daugherty, SE., et al. 2007. Prostate. 67: 1487-97. PMID: 17680641
- Sequence variation in alpha-methylacyl-CoA racemase and risk of early-onset and familial prostate cancer. | Levin, AM., et al. 2007. Prostate. 67: 1507-13. PMID: 17683075
- Variants in the alpha-Methylacyl-CoA racemase gene and the association with advanced distal colorectal adenoma. | Daugherty, SE., et al. 2007. Cancer Epidemiol Biomarkers Prev. 16: 1536-42. PMID: 17684125
- Alpha-methylacyl CoA racemase in pulmonary adenocarcinoma, squamous cell carcinoma, and neuroendocrine tumors: expression and survival analysis. | Shilo, K., et al. 2007. Arch Pathol Lab Med. 131: 1555-60. PMID: 17922592
- Relapsing encephalopathy in a patient with alpha-methylacyl-CoA racemase deficiency. | Thompson, SA., et al. 2008. J Neurol Neurosurg Psychiatry. 79: 448-50. PMID: 18032455
- Molecular cloning and preliminary analysis of the human alpha-methylacyl-CoA racemase promoter. | Chen, W., et al. 2009. Mol Biol Rep. 36: 423-30. PMID: 18080842
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
P504S Antibody (2A10F3) | sc-81710 | 200 µg/ml | $316.00 | |||
P504S Antibody (2A10F3): m-IgGλ BP-HRP Bundle | sc-521180 | 200 µg Ab, 40 µg BP | $354.00 | |||
P504S Antibody (2A10F3): m-IgG2b BP-HRP Bundle | sc-549559 | 200 µg Ab; 10 µg BP | $354.00 | |||
P504S Antibody (2A10F3) AC | sc-81710 AC | 500 µg/ml, 25% agarose | $416.00 | |||
P504S Antibody (2A10F3) HRP | sc-81710 HRP | 200 µg/ml | $316.00 | |||
P504S Antibody (2A10F3) FITC | sc-81710 FITC | 200 µg/ml | $330.00 | |||
P504S Antibody (2A10F3) PE | sc-81710 PE | 200 µg/ml | $343.00 | |||
P504S Antibody (2A10F3) Alexa Fluor® 488 | sc-81710 AF488 | 200 µg/ml | $357.00 | |||
P504S Antibody (2A10F3) Alexa Fluor® 546 | sc-81710 AF546 | 200 µg/ml | $357.00 | |||
P504S Antibody (2A10F3) Alexa Fluor® 594 | sc-81710 AF594 | 200 µg/ml | $357.00 | |||
P504S Antibody (2A10F3) Alexa Fluor® 647 | sc-81710 AF647 | 200 µg/ml | $357.00 | |||
P504S Antibody (2A10F3) Alexa Fluor® 680 | sc-81710 AF680 | 200 µg/ml | $357.00 | |||
P504S Antibody (2A10F3) Alexa Fluor® 790 | sc-81710 AF790 | 200 µg/ml | $357.00 |