PKC ζ Pseudo-substrate inhibitor, Myristoylated
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PKC ζ Pseudo-substrate inhibitor, Myristoylated (ZIP) is a cell-permeable, reversible, substrate competitive, myristoylated form of the protein kinase C ζ isozyme pseudosubstrate inhibitory peptide (sc-3098) found to inhibit an atypical type of Protein Kinase C ζ (zeta). PKC ζ Pseudo-substrate inhibitor, Myristoylated may act to also interact with PKC family isoforms and disrupt conventional PKC targeting and translocation leading to physiological memory impairment. The sequence corresponds to the pseudosubstrate region of the N-terminal regulatory domain that maintains the enzyme in an inactive form in the absence of activator. PKC ζ Pseudo-substrate inhibitor, Myristoylated has also been shown to be a competitive inhibitor of PKC ζ in neurons. PKC ζ Pseudo-substrate inhibitor, Myristoylated was also used to demonstrate that PKC ζ is involved in the regulation of integrin-dependent adhesion and chemotaxis of intact human neutrophils.
PKC ζ Pseudo-substrate inhibitor, Myristoylated References
- Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes. An apparent requirement for activation of Glut4 translocation and glucose transport. | Standaert, ML., et al. 1999. J Biol Chem. 274: 14074-8. PMID: 10318822
- Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes. | Sajan, MP., et al. 1999. J Biol Chem. 274: 30495-500. PMID: 10521430
- Protein kinase C zeta phosphorylates a subset of selective sites of the NADPH oxidase component p47phox and participates in formyl peptide-mediated neutrophil respiratory burst. | Dang, PM., et al. 2001. J Immunol. 166: 1206-13. PMID: 11145703
- Ceramide disables 3-phosphoinositide binding to the pleckstrin homology domain of protein kinase B (PKB)/Akt by a PKCzeta-dependent mechanism. | Powell, DJ., et al. 2003. Mol Cell Biol. 23: 7794-808. PMID: 14560023
- Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes. Potential role in glucose transport. | Standaert, ML., et al. 1997. J Biol Chem. 272: 30075-82. PMID: 9374484
- Evidence of zeta protein kinase C involvement in polymorphonuclear neutrophil integrin-dependent adhesion and chemotaxis. | Laudanna, C., et al. 1998. J Biol Chem. 273: 30306-15. PMID: 9804792
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PKC ζ Pseudo-substrate inhibitor, Myristoylated, 1 mg | sc-397537 | 1 mg | $207.00 |