Molecular structure of Ro 31-8220, CAS Number: 138489-18-6
Ro 31-8220 (CAS 138489-18-6)
See product citations (17)
Alternate Names:
Bisindolylmaleimide IX Methanesulfonate; BIM IX
Application:
Ro 31-8220 is a cell-permeable PKC inhibitor that has been shown to be selective for PKC over CaM kinase II and PKA
CAS Number:
138489-18-6
Purity:
≥98%
Molecular Weight:
553.65
Molecular Formula:
C25H23N5O2S•CH4O3S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Ro 31-8220, a staurosporine (sc-3510) analog, is a cell-permeable inhibitor of PKC (protein kinase C) isoforms PKC alpha, PKC betaI, PKC betaII, PKC gamma, and PKC epsilon (IC50 = 5, 24, 14, 27, and 24 nM, respectively). Ro 31-8220 has also been shown to induce apoptosis in various cell lines, independent of its PKC activity, and to inhibit GSK 3 (IC50 = 6.8nM). Ro 31-8220 is an inhibitor of Cdk2, cyclin A, GSK-3beta, MSK1, Pim-3, Polycystin-1, PRK2, Rsk-1 and Rsk-2 and an activator of JNK1.
Ro 31-8220 (CAS 138489-18-6) References
- RO 31-8220 activates c-Jun N-terminal kinase and glycogen synthase in rat adipocytes and L6 myotubes. Comparison to actions of insulin. | Standaert, ML., et al. 1999. Endocrinology. 140: 2145-51. PMID: 10218965
- The protein kinase C inhibitors bisindolylmaleimide I (GF 109203x) and IX (Ro 31-8220) are potent inhibitors of glycogen synthase kinase-3 activity. | Hers, I., et al. 1999. FEBS Lett. 460: 433-6. PMID: 10556511
- Ro 31-8220 inhibits release of interleukin-1 and interleukin-6 from mouse peritoneal macrophages induced by fibrin fibrinogen degradation products. | Zhou, B., et al. 1999. Zhongguo Yao Li Xue Bao. 20: 449-51. PMID: 10678095
- The staurosporine analog, Ro-31-8220, induces apoptosis independently of its ability to inhibit protein kinase C. | Han, Z., et al. 2000. Cell Death Differ. 7: 521-30. PMID: 10822275
- RO 31-8220 and RO 31-7549 show improved selectivity for protein kinase C over staurosporine in macrophages. | Dieter, P. and Fitzke, E. 1991. Biochem Biophys Res Commun. 181: 396-401. PMID: 1958208
- Microbial alkaloid staurosporine induces formation of nanometer-wide membrane tubular extensions (cytonemes, membrane tethers) in human neutrophils. | Galkina, SI., et al. 2010. Cell Adh Migr. 4: 32-8. PMID: 20009568
- PKC inhibitors RO 31-8220 and Gö 6983 enhance epinephrine-induced platelet aggregation in catecholamine hypo-responsive platelets by enhancing Akt phosphorylation. | Kim, SY., et al. 2011. BMB Rep. 44: 140-5. PMID: 21345315
- Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220. | Mayati, A., et al. 2015. PLoS One. 10: e0144667. PMID: 26657401
- Selective effects of the PKC inhibitors Ro 31-8220 and CGP 41,251 on PMN locomotion, cell polarity, and pinocytosis. | Keller, HU. and Niggli, V. 1994. J Cell Physiol. 161: 526-36. PMID: 7962133
- Inhibition by Ro 31-8220 of acid secretory activity induced by carbachol indicates a stimulatory role for protein kinase C in the action of muscarinic agonists on isolated rat parietal cells. | McKenna, JP. and Hanson, PJ. 1993. Biochem Pharmacol. 46: 583-8. PMID: 8363630
- RO 31-8220, a novel protein kinase C inhibitor, inhibits early and late T cell activation events. | Geiselhart, L., et al. 1996. Transplantation. 61: 1637-42. PMID: 8669110
- The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N-terminal kinase. | Beltman, J., et al. 1996. J Biol Chem. 271: 27018-24. PMID: 8900190
- Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. | Shen, L. and Glazer, RI. 1998. Biochem Pharmacol. 55: 1711-9. PMID: 9634008
Inhibitor of:
0610012H03Rik, 0610037D15Rik, 0710008K08Rik, 1100001G20Rik, 1110002B05Rik, 14-3-3 η, 1700016H13Rik, 9130404H23Rik, 9230113P08Rik, ACAM, Adducin γ, AKAP 14, AKAP 150, AMMECR1, ANKRD18B, APMSF, ARH2, ARHGEF10L, B230218P12Rik, BIN2, BRINP2, BTN2A2, C3orf32, C8orf31, Cabin-1, CapZIP, CARMIL, CBF-B, Cdk2, CDP2, cfm, CIB4, CLEC-2A, copine 8, cPKC α, cPKC βI, cPKC γ, CREB-1, CREB-2, cyclin A, DAP-4, DCC, DDX60, DMRTA2, Doc2g, EG243866, EG667512, EGFL10, Fpr-rs6, GIMAP7, GPATCH1, GRK 1, GRK 7, GS188, Gucy2g, HCC-4, HDDC2, HIV-1 Vpr, HKr18, HMP19, hnRNP UL2, HNRPLL, HSTF1, ICA1L, IDE, IFT122, Ikaros 5, IQCD, Islet-1, JM4, KBTBD8, KIAA0528, Kruppel, LCE1B, LIN-7, LOC100041339, LOC390937_EG232974, LOC401317, LRFN1, LYPD6, MAPKAP-1, MARCKS, MCTS2, mGBP8, MPP3, MRFAP1, MSK1, Msx-2, Neurogranin, NIPSNAP1, NP220, nPKC ζ, Olfr44, Olfr492, Otg1, OTOGL, OTTMUSG00000010173, Palmdelphin, Paralemmin 2, Pbx2, Pcdhb20, Per 2, Pim-3, PITPβ, PKC, PKC ε, PKC η, PKC ζ, PKC beta, PKC-d2, PLC η1, PLC-L, Polycystin-1, PREP-2, PRK1, PRK2, Prpmp5, PTRF, RBJ, RBM33, REM2, RLBP1L2, ROPN1L, Rsk-1, Rsk-2, RWDD1, S-100A10, SART-3, Scratch2, SEMA6A, Ser/Thr Protein Kinase, Shank 2, SIV-1 Nef, Slp3, SNAPC 19, Sox-14, Sox-6, SPEN, Sslp-1, STH, Synapsin Ia, Synapsin Ia/b, Synapsin IIb, TAX-2, Tenrl, TM4SF20, TMEM132B, TSSK 3, utrophin, V3R 11, V3R 4, VEZF1, Vmn1r118, Vmn2r15, ZC3H12C, ZC3H14, ZFP105, ZFP54, ZFP60, ZIP, ZNF10, ZNF155, ZNF312, and ZNF845.Activator of:
ADAM24, ADAM30, ADAM6A, ARHGEF17, C130079G13Rik, CapG, Eapa2, HSV-2 gG Envelope Protein, HTLV-2 p19, IFFO2, INDOL1, JNK1, KCNQ3, KIF20A, LLGL1, LOC147670, NCOAT, NKR-P1F, NKTR, NPC Marker, Olr175, OTTMUSG00000015050, OTTMUSG00000015173, OTTMUSG00000015220, OTTMUSG00000015279, OTTMUSG00000015337, OTTMUSG00000015417, PCLN-1, PKC ν, plakophilin 4, Plb2, PLEKHJ1, Pol III RPC62, RACK1, RAG-1, Ran BP-2, RBM42, SPUVE, SSXB8, STAP-2, TEX28, TMEM205, U2AF1L3, ZFP36L3, and ZNF573.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ro 31-8220, 1 mg | sc-200619 | 1 mg | $90.00 | |||
Ro 31-8220, 5 mg | sc-200619A | 5 mg | $240.00 |