Date published: 2025-9-11

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Rolipram (CAS 61413-54-5)

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Alternate Names:
SB 95952; ZK 62711
Application:
Rolipram is a selective, cell permeable inhibitor of cAMP-specific phosphodiesterase (PDE4)
CAS Number:
61413-54-5
Purity:
≥97%
Molecular Weight:
275.35
Molecular Formula:
C16H21NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Rolipram is a selective, cell-permeable inhibitor of cAMP-specific PDE (phosphodiesterase) (PDE4, IC50=1 muM). This compound may act to inhibit PDE4 activity in human cavernosal tissue, which interrupts the signal transduction pathway of erectile response. Rolipram promotes apoptosis in HL60 cells through a cAMP-independent mechanism and may act to enhance neuronal survival. Rolipram is an inhibitor of PDE4A1 and PDE4B.


Rolipram (CAS 61413-54-5) References

  1. Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4).  |  Bivalacqua, TJ., et al. 1999. J Urol. 162: 1848-55. PMID: 10524946
  2. Bemoradan--a novel inhibitor of the rolipram-insensitive cyclic AMP phosphodiesterase from canine heart tissue.  |  Moore, JB., et al. 1991. Biochem Pharmacol. 42: 679-83. PMID: 1650219
  3. The phosphodiesterase inhibitor rolipram promotes survival of newborn hippocampal neurons after ischemia.  |  Sasaki, T., et al. 2007. Stroke. 38: 1597-605. PMID: 17379823
  4. Effects of rolipram on U46619-induced contraction and cyclic nucleotide content in the porcine coronary artery.  |  Kaneda, T., et al. 2010. J Smooth Muscle Res. 46: 17-29. PMID: 20383031
  5. Rolipram promotes functional recovery after contusive thoracic spinal cord injury in rats.  |  Costa, LM., et al. 2013. Behav Brain Res. 243: 66-73. PMID: 23295392
  6. Rolipram improves renal perfusion and function during sepsis in the mouse.  |  Holthoff, JH., et al. 2013. J Pharmacol Exp Ther. 347: 357-64. PMID: 24018639
  7. The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity.  |  Doseyici, S., et al. 2014. Biotech Histochem. 89: 388-92. PMID: 24520882
  8. Effects of rolipram and zaprinast on learning and memory in the Morris water maze and radial arm maze tests in naive mice.  |  Akar, F., et al. 2015. Drug Res (Stuttg). 65: 86-90. PMID: 24764251
  9. Zaprinast and rolipram enhances spatial and emotional memory in the elevated plus maze and passive avoidance tests and diminishes exploratory activity in naive mice.  |  Akar, F., et al. 2014. Med Sci Monit Basic Res. 20: 105-11. PMID: 25057848
  10. Activation of Hippocampal CREB by Rolipram Partially Recovers Balance Between TNF-α and IL-10 Levels and Improves Cognitive Deficits in Diabetic Rats.  |  Miao, Y., et al. 2015. Cell Mol Neurobiol. 35: 1157-64. PMID: 26001770
  11. The Analgesic Effect of Rolipram, a Phosphodiesterase 4 Inhibitor, on Chemotherapy-Induced Neuropathic Pain in Rats.  |  Kim, HK., et al. 2015. Anesth Analg. 121: 822-828. PMID: 26214551
  12. Stereospecific binding of the antidepressant rolipram to brain protein structures.  |  Schneider, HH., et al. 1986. Eur J Pharmacol. 127: 105-15. PMID: 3019721
  13. The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Implications for the mechanism of action of selective phosphodiesterase inhibitors.  |  Reeves, ML., et al. 1987. Biochem J. 241: 535-41. PMID: 3036066
  14. Comparison of phosphodiesterase III, IV and dual III/IV inhibitors on bronchospasm and pulmonary eosinophil influx in guinea pigs.  |  Underwood, DC., et al. 1994. J Pharmacol Exp Ther. 270: 250-9. PMID: 8035322
  15. Cyclic AMP-specific phosphodiesterase inhibitor rolipram and RO-20-1724 promoted apoptosis in HL60 promyelocytic leukemic cells via cyclic AMP-independent mechanism.  |  Zhu, WH., et al. 1998. Life Sci. 63: 265-74. PMID: 9698035

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Rolipram, 5 mg

sc-3563
5 mg
$75.00

Rolipram, 50 mg

sc-3563A
50 mg
$212.00