Date published: 2025-12-13

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Suberanilic Acid (CAS 149648-52-2)

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Alternate Names:
8-Oxo-8-(phenylamino)octanoic Acid
Application:
Suberanilic Acid is An intermediate in the production of Suberoylanilide Hydroxamic Acid and other histone deacetylase inhibitors.
CAS Number:
149648-52-2
Molecular Weight:
249.31
Molecular Formula:
C14H19NO3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Suberanilic Acid is a compound widely studied in materials science, particularly for its applications in creating novel polymers and fluorescent materials. Its ability to form stable diazo compounds makes it a valuable reagent in synthesizing azo dyes, which are extensively used in textile and printing industries. Researchers also explore Suberanilic Acid for its potential in organic electronics, where its conductive properties are of interest for developing new types of organic semiconductors. In the field of analytical chemistry, Suberanilic Acid is investigated for its role in creating sensitive and selective sensors, which can detect metal ions and organic compounds. Additionally, due to its light-absorbing characteristics, it is used in photophysical studies to understand the behavior of aromatic compounds under various light conditions.


Suberanilic Acid (CAS 149648-52-2) References

  1. A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.  |  Gediya, LK., et al. 2005. J Med Chem. 48: 5047-51. PMID: 16033284
  2. SEROLOGICAL STUDIES ON AZOPROTEINS : ANTIGENS CONTAINING AZOCOMPONENTS WITH ALIPHATIC SIDE CHAINS.  |  Landsteiner, E. and van der Scheer, J. 1934. J Exp Med. 59: 751-68. PMID: 19870277
  3. ON CROSS REACTIONS OF IMMUNE SERA TO AZOPROTEINS.  |  Landsteiner, K. and van der Scheer, J. 1936. J Exp Med. 63: 325-39. PMID: 19870475
  4. Suberoylanilide hydroxamic acid, a potent histone deacetylase inhibitor; its X-ray crystal structure and solid state and solution studies of its Zn(II), Ni(II), Cu(II) and Fe(III) complexes.  |  Griffith, DM., et al. 2011. J Inorg Biochem. 105: 763-9. PMID: 21496451
  5. (7-Diethylaminocoumarin-4-yl)methyl ester of suberoylanilide hydroxamic acid as a caged inhibitor for photocontrol of histone deacetylase activity.  |  Ieda, N., et al. 2016. Bioorg Med Chem. 24: 2789-93. PMID: 27143132
  6. Novel SAHA analogues inhibit HDACs, induce apoptosis and modulate the expression of microRNAs in hepatocellular carcinoma.  |  Srinivas, C., et al. 2016. Apoptosis. 21: 1249-1264. PMID: 27502208
  7. An epigenetic modifier induces production of 3-(4-oxopyrano)-chromen-2-ones in Aspergillus sp. AST0006, an endophytic fungus of Astragalus lentiginosus.  |  de Amorim, MR., et al. 2020. Tetrahedron. 76: PMID: 33716326
  8. Novel Suberoylanilide Hydroxamic Acid Analogs Inhibit Angiogenesis and Induce Apoptosis in Breast Cancer Cells.  |  Moku, G., et al. 2022. Anticancer Agents Med Chem. 22: 914-925. PMID: 34488592
  9. The endophytic Aspergillus strains: A bountiful source of natural products.  |  Hagag, A., et al. 2022. J Appl Microbiol. 132: 4150-4169. PMID: 35157354
  10. Synthesis, in vitro and structural aspects of cap substituted Suberoylanilide hydroxamic acid analogs as potential inducers of apoptosis in Glioblastoma cancer cells via HDAC /microRNA regulation.  |  Mekala, JR., et al. 2022. Chem Biol Interact. 357: 109876. PMID: 35283086
  11. Photoresponsive Small Molecule Inhibitors for the Remote Control of Enzyme Activity.  |  Laczi, D., et al. 2022. Chem Asian J. 17: e202200200. PMID: 35446477
  12. Elucidation of the working principle of a gene-directed caged HDAC inhibitor with cell-type selectivity.  |  Sakamoto, K., et al. 2022. Chem Commun (Camb). 58: 10484-10487. PMID: 36040293
  13. The synthesis of N-hydroxy-N'-phenyloctanediamide and its inhibitory effect on proliferation of AXC rat prostate cancer cells.  |  Stowell, JC., et al. 1995. J Med Chem. 38: 1411-3. PMID: 7731025

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Suberanilic Acid, 200 mg

sc-220136
200 mg
$220.00