U-73343 (CAS 142878-12-4)

U-73343, a structural analog of U-73122 (sc-3574), distinguishes itself by lacking the ability to inhibit phospholipase C (PLC) activity, unlike U-73122. This differentiation arises from the substitution of the pyrrolidinedione moiety in U-73122 with a pyrroledione group in U-73343, eliminating its antagonism towards phospholipase C. As a consequence, U-73343 serves as a valuable negative control in investigations focused on U-73122′s phospholipase C antagonism and its associated cellular outcomes. Additionally, U-73343 acts as a non-peptide, small molecule agonist specifically targeting the human adenosine A2A receptor (A2AR). It demonstrates potent and selective agonistic properties towards the A2AR, with a Ki value of 0.6 nM and an EC50 value of 1.6 nM. Extensive studies have explored U-73343, unveiling a range of biological activities encompassing anti-inflammatory, anti-allergic, and anti-cancer effects. The human adenosine A2A receptor (A2AR), a G-protein coupled receptor expressed in various tissues such as the brain, heart, and lungs, serves as the primary target for U-73343. Upon binding to the A2AR, U-73343 activates the receptor, initiating downstream signaling pathways involved in key biological processes, including inflammation regulation, immune response modulation, and cell proliferation control. Significant research efforts have showcased the diverse biological activities of U-73343. Notably, it has demonstrated efficacy in reducing airway inflammation in an asthma model, mitigating inflammation in a colitis model, and inhibiting the growth of lung cancer cells.