Molecular structure of Vardenafil, CAS Number: 224785-90-4
Vardenafil (CAS 224785-90-4)
See product citations (7)
Alternate Names:
Levitra
Application:
Vardenafil is a selective inhibitor of cGMP-specific phosphodiesterase type 5 (PDE5)
CAS Number:
224785-90-4
Purity:
≥97%
Molecular Weight:
488.60
Molecular Formula:
C23H32N6O4S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Vardenafil is a PDE (phosphodiesterase) inhibitor that is selective for PDE5 and PDE1 (IC50 = 0.7 and 180 nM, respectively). Vardenafil is closely related to sildenafil and tadalafil in structure as well as function. Inhibition of PDE enzymes prevents the breakdown of secondary messenger molecules, enhancing the effect of signal transduction.
Vardenafil (CAS 224785-90-4) References
- Hepatoprotective role of vardenafil against experimentally induced hepatitis in mice. | Ahmed, N., et al. 2017. J Biochem Mol Toxicol. 31: PMID: 27762466
- Vardenafil reduces macrophage pro-inflammatory overresponses in cystic fibrosis through PDE5- and CFTR-dependent mechanisms. | Noel, S., et al. 2017. Clin Sci (Lond). 131: 1107-1121. PMID: 28196856
- Vardenafil inhibiting parasympathetic function of tracheal smooth muscle. | Lee, FP., et al. 2018. J Chin Med Assoc. 81: 631-635. PMID: 29395941
- Targeting Phosphodiesterase-5 by Vardenafil Improves Vascular Graft Function. | Veres, G., et al. 2018. Eur J Vasc Endovasc Surg. 56: 256-263. PMID: 29724533
- Pituitary adenoma apoplexy associated with vardenafil intake. | Uneda, A., et al. 2019. Acta Neurochir (Wien). 161: 129-131. PMID: 30542775
- Metabolic study of vardenafil analogues: Pseudovardenafil and hydroxyvardenafil. | Heo, D., et al. 2020. J Chromatogr B Analyt Technol Biomed Life Sci. 1139: 121940. PMID: 31978742
- The Phosphodiesterase-5 Inhibitor Vardenafil Improves the Activation of BMP Signaling in Response to Hydrogen Peroxide. | Mao, F., et al. 2020. Cardiovasc Drugs Ther. 34: 41-52. PMID: 32096002
- Stimulating effects of vardenafil, tadalafil, and udenafil on vascular endothelial growth factor, angiogenesis, vitamin D3, bone morphogenic proteins in ovariectomized rats. | Huyut, Z., et al. 2022. Arch Physiol Biochem. 128: 1121-1127. PMID: 32314927
- Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells. | Dhooghe, B., et al. 2020. Biol Open. 9: PMID: 32747447
- Functional metabolomics reveal the role of AHR/GPR35 mediated kynurenic acid gradient sensing in chemotherapy-induced intestinal damage. | Wang, D., et al. 2021. Acta Pharm Sin B. 11: 763-780. PMID: 33777681
- Effects of different vardenafil doses on bone healing in a rat fracture model. | Atcı, T., et al. 2021. Jt Dis Relat Surg. 32: 313-322. PMID: 34145806
- Vardenafil oral jellies as a potential approach for management of pediatric irritable bowel syndrome. | Gomaa, E. and Ayoub, MM. 2021. Saudi Pharm J. 29: 955-962. PMID: 34588841
- Renoprotective Effect of Vardenafil and Avanafil in Contrast-Induced Nephropathy: Emerging Evidence from an Animal Model. | Zisis, IE., et al. 2022. J Pers Med. 12: PMID: 35629096
- Survey on Sildenafil, Tadalafil, and Vardenafil Concentrations in Food Supplements for Erectile Dysfunction. | Petkova-Gueorguieva, E., et al. 2022. Int J Anal Chem. 2022: 3950190. PMID: 35855809
- The PDE5 inhibitor, vardenafil, ameliorates progressive pathological changes in a focal segmental glomerulosclerosis mouse model. | Hu, SW., et al. 2022. Life Sci. 309: 120992. PMID: 36155178
Inhibitor of:
6430550D23Rik, 9430015G10Rik9, A26C1B, A630023A22Rik, AA416372, AB056442, AGAP3, BBS12, C22orf13, cGKI alpha, Dexras2, Enzyme, Guanylate Cyclase (GUCA), Olfr1065, Olfr107, Olr14, Olr556, Olr557, Olr577, Olr611, Olr614, Olr634, Olr636, Olr639, PCMTD2, PDE, PDE6, PDE6Aα, PDE6G, PDE6H, PP5, RD3L, RPGR, Semenogelin-1, TBX4, and TEF-5.Activator of:
ε-sarcoglycan, 2′-PDE, 6430548M08Rik, A330050F15Rik, ADAL, ATP6E, Basal ciliated, BC031181, BONO1, Brn-3c, BTNL2, c-GMP, C14orf145, C5orf23, CAP2, CCK-AR, CCXCKR, CD177, CD200R3, CdcA7, cGKI, cGKI α, cGKII, Chromozym PK, CNG-β3, CNG-1, CNG-1β, CNG-2, Cngb1, CRF21, DPCD, EG667705, ELSPBP1, FSCB, Gγ 3, Gγ 9, Gγ4, GALR1, GCAP2, GCS-α-3, GI24, Gm12, Gm129, GPCR2037, GPR179, GPR26, GPR63, GPR89, GRK 1, GSBS, GUCD1, Gucy2d, Gucy2g, HAP1, HCN2, HMW-Guanylin, HOM-TES-103, HSPC144, ICA1L, JK-1, kallistatin, KIR4.2, LOC338667, LOC388564, LRRC50, Mas 7, MCH-2R, MG50, MRP-L32, MSG1, Olfr1008, Olfr1079, Olfr1090, Olfr392, Olfr739, Olr242, Olr25, Olr252, Olr257, Olr264, Olr27, Olr272, Olr286, Olr3, Olr309, Olr322, Olr336, Olr348, Olr357, Olr363, Olr37, Olr375, Olr390, Olr400, Olr402, Olr408, Olr410, Olr415, Olr419, Olr421, Olr434, OPN1MW2, OR10AD1, OR10P1, OR2A12, OR2C1, OR4A16, OR4D6, OR4K5, OR4M1, OR4S2, OR5AS1, OR5B21, OR5V1, OR6C2, OR6C4, OR6C65, OR6C70, OR6C75, OR6K2, OR8K1, OR8K5, OR9G4, OR9K2, Otospiralin, OVCH2, PDE10A, PDE11A, PDE1C, PDE4C, PDE5A, PDE6α, PDE6H, PDE8A, PDZK2, PKAα cat, PKR2, PRRG3, Psf1, RAPGEF5, rcRPE, Relaxin Receptor 3, Relaxin Receptor 4, RGS11, RGS7, RGS9, Rim2, ROS-GC2, secretin, sGC α1, sGC α2, sGC β1, sGC β2, SLC17A9, SR-6, StARD8, SVOPL, t-GMP, THEG, TMEM150B, TMEM218, TMEM25, TPPP, TREK-1, Trp6, TSARG6, USH3A, V1RD15, V1RD17, V1RD19, V1RD20, V1RD22, V1RD4, V3R 6, V3R 8, and WBSCR19.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Vardenafil, 100 mg | sc-362054 | 100 mg | $516.00 | |||
Vardenafil, 1 g | sc-362054A | 1 g | $720.00 | |||
Vardenafil, 50 g | sc-362054B | 50 g | $16326.00 |