CD42b Antibody (SZ2): sc-59052

CD42b Antibody (SZ2) is a mouse monoclonal IgG1 antibody that detects CD42b of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). Anti-CD42b antibody (SZ2) is available in non-conjugated form. CD42b, also known as glycoprotein Ib α (GPIb α), is a crucial membrane glycoprotein composed of α and β chains, with the β chain also referred to as CD42c. CD42b is predominantly expressed on platelets and megakaryocytes, where CD42b plays a vital role in hemostasis by serving as a receptor for von Willebrand′s factor (vWF). The interaction between CD42b and vWF is essential for platelet adhesion to the vascular endothelium at sites of injury, thereby facilitating the formation of a platelet plug and preventing excessive bleeding. The complex formed by CD42a and CD42b is a major component of the platelet surface, underscoring CD42b′s importance in the regulation of platelet function and the overall coagulation process. CD42b (SZ2) antibody in various applications helps researchers gain insights into the mechanisms of platelet activation and the pathophysiology of bleeding disorders, making CD42b (SZ2) antibody an invaluable tool in both basic and clinical research.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

CD42b Antibody (SZ2) References:

1. Selectins (CD62L, CD62P) and megakaryocytic glycoproteins (CD41a, CD42b) mediate megakaryocyte-fibroblast interactions in human bone marrow.  |  Wickenhauser, C., et al. 2000. Leuk Res. 24: 1013-21. PMID: 11077115
2. Platelets and blood vessels: the adhesion event.  |  Roth, GJ. 1992. Immunol Today. 13: 100-5. PMID: 1622541
3. Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b).  |  Mäyränpää, MI., et al. 2007. Endothelium. 14: 81-7. PMID: 17497364
4. Endocytosed factor V is trafficked to CD42b+ proplatelet extensions during differentiation of human umbilical cord blood-derived megakaryocytes.  |  Gertz, JM., et al. 2018. J Cell Physiol. 233: 8691-8700. PMID: 29761851
5. GPIbα is required for platelet-mediated hepatic thrombopoietin generation.  |  Xu, M., et al. 2018. Blood. 132: 622-634. PMID: 29794068
6. The alpha and beta chains of human platelet glycoprotein Ib are both transmembrane proteins containing a leucine-rich amino acid sequence.  |  Lopez, JA., et al. 1988. Proc Natl Acad Sci U S A. 85: 2135-9. PMID: 3353370
7. Detection of transient abnormal myelopoiesis blasts in a liver biopsy specimen by double-immunostaining for full-length GATA1 and CD42b.  |  Haba, A., et al. 2023. Hematology. 28: 2240135. PMID: 37489937
8. Bernard-Soulier syndrome Kagoshima: Ser 444-->stop mutation of glycoprotein (GP) Ib alpha resulting in circulating truncated GPIb alpha and surface expression of GPIb beta and GPIX.  |  Kunishima, S., et al. 1994. Blood. 84: 3356-62. PMID: 7949089
9. Structural characterization and chromosomal location of the gene encoding human platelet glycoprotein Ib beta.  |  Yagi, M., et al. 1994. J Biol Chem. 269: 17424-7. PMID: 8021244
10. Glycoprotein (GP) Ib beta is the critical subunit linking GP Ib alpha and GP IX in the GP Ib-IX complex. Analysis of partial complexes.  |  López, JA., et al. 1994. J Biol Chem. 269: 23716-21. PMID: 8089142
11. Complementary DNA cloning of the alternatively expressed endothelial cell glycoprotein Ib beta (GPIb beta) and localization of the GPIb beta gene to chromosome 22.  |  Kelly, MD., et al. 1994. J Clin Invest. 93: 2417-24. PMID: 8200976
12. Characterization of the gene encoding human platelet glycoprotein IX.  |  Hickey, MJ. and Roth, GJ. 1993. J Biol Chem. 268: 3438-43. PMID: 8429020

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-CD42b Antibody (SZ2) has 7 citations in a variety of scientific publications.

Primary antibodies like Anti-CD42b Antibody (SZ2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

CD42b Antibody (SZ2) Specifications

Alternate Product Name: CD42b

Product Clone Name: SZ2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: CD42b

Epitope Species: human

Product Reactivity/Detection: CD42b

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and 1% stabilizer protein

Research Citations: 7 citations in various scientific publications

Available Conjugates/Forms for CD42b Antibody (SZ2): N/A