Date published: 2025-12-13

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Genistein (CAS 446-72-0)

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Alternate Names:
Genistein is also known as Prunetol.
Application:
Genistein is naturally occurring isoflavone, phytoestrogen, and highly specific inhibitor of protein tyrosine kinase (PTK).
CAS Number:
446-72-0
Purity:
>98%
Molecular Weight:
270.24
Molecular Formula:
C15H10O5
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Genistein, a phytoestrogen found in soy products, is a highly specific inhibitor of protein tyrosine kinase (PTK). Additionally, Genistein is a competitive inhibitor of ATP in other protein kinase reactions. Genistein inhibits tyrosine phosphorylation in isolated enzyme and receptor preparations and in whole cells including platelets, lymphocytes and a variety of cultured cells. Genistein also inhibits EGF-stimulated phosphorylation in cultured cells. In cultured A431 epidermoid carcinoma cells, EGF-stimulated tyrosine phosphorylation was completely inhibited by Genistein at 100 mug/ml. Inhibition by Genistein is competitive with ATP and noncompetitive with substrates.


Genistein (CAS 446-72-0) References

  1. Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with genistein and monoclonal antibody to phosphotyrosine.  |  Dhar, A., et al. 1990. Mol Pharmacol. 37: 519-25. PMID: 1691437
  2. The role of tyrosine phosphorylation in signal transduction through surface Ig in human B cells. Inhibition of tyrosine phosphorylation prevents intracellular calcium release.  |  Lane, PJ., et al. 1991. J Immunol. 146: 715-22. PMID: 1702814
  3. T cell antigen receptor-mediated activation of phospholipase C requires tyrosine phosphorylation.  |  Mustelin, T., et al. 1990. Science. 247: 1584-7. PMID: 2138816
  4. Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity.  |  Linassier, C., et al. 1990. Biochem Pharmacol. 39: 187-93. PMID: 2153378
  5. Effect of genistein, a tyrosine kinase inhibitor, on U46619-induced phosphoinositide phosphorylation in human platelets.  |  Gaudette, DC. and Holub, BJ. 1990. Biochem Biophys Res Commun. 170: 238-42. PMID: 2164806
  6. Differential inhibition of T cell receptor signal transduction and early activation events by a selective inhibitor of protein-tyrosine kinase.  |  Trevillyan, JM., et al. 1990. J Immunol. 145: 3223-30. PMID: 2172380
  7. Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells.  |  Dean, NM., et al. 1989. Biochem Biophys Res Commun. 165: 795-801. PMID: 2532009
  8. Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.  |  Markovits, J., et al. 1989. Cancer Res. 49: 5111-7. PMID: 2548712
  9. An Overview on Genistein and its Various Formulations.  |  Jaiswal, N., et al. 2019. Drug Res (Stuttg). 69: 305-313. PMID: 30517965
  10. Genistein, a specific inhibitor of tyrosine-specific protein kinases.  |  Akiyama, T., et al. 1987. J Biol Chem. 262: 5592-5. PMID: 3106339
  11. Emerging Signal Regulating Potential of Genistein Against Alzheimer's Disease: A Promising Molecule of Interest.  |  Uddin, MS. and Kabir, MT. 2019. Front Cell Dev Biol. 7: 197. PMID: 31620438
  12. Genistein as Potential Therapeutic Candidate for Menopausal Symptoms and Other Related Diseases.  |  Thangavel, P., et al. 2019. Molecules. 24: PMID: 31671813
  13. Genistein as a regulator of signaling pathways and microRNAs in different types of cancers.  |  Javed, Z., et al. 2021. Cancer Cell Int. 21: 388. PMID: 34289845
  14. Cellular and molecular mechanisms of genistein in prevention and treatment of diseases: An overview.  |  Nazari-Khanamiri, F. and Ghasemnejad-Berenji, M. 2021. J Food Biochem. 45: e13972. PMID: 34664285
  15. Genistein-Opportunities Related to an Interesting Molecule of Natural Origin.  |  Garbiec, E., et al. 2022. Molecules. 27: PMID: 35164079

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Genistein, 100 mg

sc-3515
100 mg
$26.00

Genistein, 500 mg

sc-3515A
500 mg
$92.00

Genistein, 1 g

sc-3515B
1 g
$120.00

Genistein, 5 g

sc-3515C
5 g
$310.00

Genistein, 10 g

sc-3515D
10 g
$500.00

Genistein, 25 g

sc-3515E
25 g
$908.00

Genistein, 100 g

sc-3515F
100 g
$1821.00