Molecular structure of 2′-Deoxyinosine, CAS Number: 890-38-0
2′-Deoxyinosine (CAS 890-38-0)
See product citations (2)
Alternate Names:
9-(2-Deoxy-β-D-ribofuranosyl)hypoxanthine
Application:
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond
CAS Number:
890-38-0
Purity:
≥98%
Molecular Weight:
252.23
Molecular Formula:
C10H12N4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
2′-Deoxyinosine is a nucleoside composed of hypoxanthine attached to 2′-deoxyribose via a β-N9-glycosidic bond. 2′-Deoxyinosine in DNA can arise from deamination of adenosine. 2′-deoxyinsine can be used as a model compound to study the chemistry of adduct formation and radical chemistry that may affect DNA structures. 2′-Deoxyinosine is used to produce hybridization-sensitive fluorescent DNA probes with self-avoidance ability.
2′-Deoxyinosine (CAS 890-38-0) References
- Lipase-catalyzed protection of the hydroxy groups of the nucleosides inosine and 2'-deoxyinosine: a new chemoenzymatic synthesis of the antiviral drug 2',3'-dideoxyinosine. | Ciuffreda, P., et al. 1999. Bioorg Med Chem Lett. 9: 1577-82. PMID: 10386939
- Thermal stability of triple helical DNAs containing 2'-deoxyinosine and 2'-deoxyxanthosine. | Ueno, Y., et al. 2004. Bioorg Med Chem. 12: 6581-6. PMID: 15556774
- Development of stealth liposome formulation of 2'-deoxyinosine as 5-fluorouracil modulator: in vitro and in vivo study. | Fanciullino, R., et al. 2005. Pharm Res. 22: 2051-7. PMID: 16222443
- Quantitative gas chromatography mass spectrometric analysis of 2'-deoxyinosine in tissue DNA. | Lim, KS., et al. 2006. Nat Protoc. 1: 1995-2002. PMID: 17487188
- Miscoding properties of 2'-deoxyinosine, a nitric oxide-derived DNA Adduct, during translesion synthesis catalyzed by human DNA polymerases. | Yasui, M., et al. 2008. J Mol Biol. 377: 1015-23. PMID: 18304575
- Hybridization-sensitive fluorescent DNA probe with self-avoidance ability. | Ikeda, S., et al. 2010. Org Biomol Chem. 8: 546-51. PMID: 20090970
- Electrochemical genotyping and detection of single-nucleotide polymorphisms based on junction-probe containing 2'-deoxyinosine. | Zhang, J., et al. 2010. Chem Commun (Camb). 46: 6986-8. PMID: 20730202
- Nucleoterpenes of thymidine and 2'-deoxyinosine: synthons for a biomimetic lipophilization of oligonucleotides. | Köstler, K., et al. 2013. Chem Biodivers. 10: 39-61. PMID: 23341207
- Chemical Constituents of Cordyceps cicadae. | Chu, ZB., et al. 2015. Nat Prod Commun. 10: 2145-6. PMID: 26882686
- Bioactivity of 2'-deoxyinosine-incorporated aptamer AS1411. | Fan, X., et al. 2016. Sci Rep. 6: 25799. PMID: 27194215
- The Bioactivity of D-/L-Isonucleoside- and 2'-Deoxyinosine-Incorporated Aptamer AS1411s Including DNA Replication/MicroRNA Expression. | Fan, X., et al. 2017. Mol Ther Nucleic Acids. 9: 218-229. PMID: 29246300
- Enhancement of exon skipping activity by reduction in the secondary structure content of LNA-based splice-switching oligonucleotides. | Shimo, T., et al. 2019. Chem Commun (Camb). 55: 6850-6853. PMID: 31123731
- Therapeutic Perspectives of Adenosine Deaminase Inhibition in Cardiovascular Diseases. | Kutryb-Zajac, B., et al. 2020. Molecules. 25: PMID: 33053898
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
2′-Deoxyinosine, 100 mg | sc-216293 | 100 mg | $33.00 | |||
2′-Deoxyinosine, 1 g | sc-216293A | 1 g | $145.00 |