ZW10 Activators
ZW10, also known as Zeste White 10 or mitotic checkpoint protein ZW10, is a critical component of the spindle assembly checkpoint (SAC), a safety mechanism ensuring correct chromosome segregation during mitosis. This protein functions as a signal transducer for the SAC by localizing to kinetochores-structures on chromosomes where spindle fibers attach-during mitosis. ZW10 is involved in delaying the onset of anaphase until all chromosomes are properly aligned and attached to the spindle, thus blocking aneuploidy, which can lead to cancer if left unchecked.
The protein interacts with other checkpoint proteins, such as Rod and Zwilch, forming the RZZ complex, which is essential for the recruitment of dynein-dynactin to kinetochores and the generation of the checkpoint signal. When chromosomes are improperly attached, ZW10 helps inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C), a ubiquitin ligase that triggers the progression into anaphase by targeting specific proteins for degradation.Besides its well-established role in mitosis, ZW10 has been implicated in other cellular processes, such as membrane trafficking and the regulation of centrosome functions. Mutations or dysregulation of ZW10 have been associated with various types of cancer due to its role in maintaining genomic stability.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
As a DNA-damaging agent, it may increase ZW10 expression as part of the cell's effort to maintain genomic stability. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
This topoisomerase inhibitor can induce DNA breaks, potentially leading to upregulation of ZW10 as a cellular response to damage. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Known to interfere with DNA replication, leading to an increase in ZW10 expression for checkpoint control. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Induces replication stress and could upregulate ZW10 as part of the response to stalled replication forks. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
A chemotherapy drug that forms DNA crosslinks and could increase ZW10 expression due to DNA damage response. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
An inhibitor of DNA polymerase, which could trigger the DNA damage checkpoint and potentially increase ZW10 expression. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Crosslinks DNA and could lead to enhanced ZW10 expression in response to genotoxic stress. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Disrupts the p53-MDM2 interaction and could induce ZW10 expression as part of the p53-mediated DNA damage response. | ||||||