Barhl1 Antibody (KA.25): sc-130465

Barhl1 Antibody (KA.25) is a mouse monoclonal IgG2a kappa light chain antibody that detects Barhl1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Barhl1 antibody (KA.25) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Barhl1, or BarH-like-1, is a crucial homeobox protein that plays a significant role in the development of the central nervous system. Specifically, Barhl1 is expressed in restricted domains of the developing diencephalon and rhombencephalon, which are vital regions for brain development. Barhl1 is involved in the regulation of cell adhesion molecules, influencing the morphogenetic processes that determine the fate of external sensory organs. Barhl1 expression in migrating cells contributes to the formation of the cerebellar external granular layer, highlighting Barhl1′s importance in neurogenesis and the proper organization of neural structures. Understanding Barhl1 function and expression patterns is essential for elucidating the mechanisms underlying neural development and potential developmental disorders.

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Barhl1 Antibody (KA.25) References:

1. Barhl1, a gene belonging to a new subfamily of mammalian homeobox genes, is expressed in migrating neurons of the CNS.  |  Bulfone, A., et al. 2000. Hum Mol Genet. 9: 1443-52. PMID: 10814725
2. Search for genes involved in Joubert syndrome: evidence that one or more major loci are yet to be identified and exclusion of candidate genes EN1, EN2, FGF8, and BARHL1.  |  Blair, IP., et al. 2002. Am J Med Genet. 107: 190-6. PMID: 11807898
3. Barhl1 regulates migration and survival of cerebellar granule cells by controlling expression of the neurotrophin-3 gene.  |  Li, S., et al. 2004. J Neurosci. 24: 3104-14. PMID: 15044550
4. Mutational analysis of BARHL1 and BARX1 in three new patients with Joubert syndrome.  |  Gould, DB. and Walter, MA. 2004. Am J Med Genet A. 131: 205-8. PMID: 15487006
5. The pro-apoptotic activity of a vertebrate Bar-like homeobox gene plays a key role in patterning the Xenopus neural plate by limiting the number of chordin- and shh-expressing cells.  |  Offner, N., et al. 2005. Development. 132: 1807-18. PMID: 15772136
6. Transcriptional regulation by Barhl1 and Brn-3c in organ-of-Corti-derived cell lines.  |  Sud, R., et al. 2005. Brain Res Mol Brain Res. 141: 174-80. PMID: 16226339
7. BARHL1 homeogene, the human ortholog of the mouse Barhl1 involved in cerebellum development, shows regional and cellular specificities in restricted domains of developing human central nervous system.  |  Lopes, C., et al. 2006. Biochem Biophys Res Commun. 339: 296-304. PMID: 16307728
8. Differential transcription of Barhl1 homeobox gene in restricted functional domains of the central nervous system suggests a role in brain patterning.  |  Rachidi, M. and Lopes, C. 2006. Int J Dev Neurosci. 24: 35-44. PMID: 16384683
9. Zebrafish BarH-like genes define discrete neural domains in the early embryo.  |  Colombo, A., et al. 2006. Gene Expr Patterns. 6: 347-52. PMID: 16448861