Barhl1 Inhibitors represent a class of chemical compounds designed to modulate the activity of the Barhl1 protein, which is a transcription factor involved in the regulation of gene expression during embryonic development, particularly in neural differentiation processes. These inhibitors are developed to specifically target the Barhl1 protein and interfere with its transcriptional activity. The objective of such inhibitors is to gain insights into the molecular mechanisms through which Barhl1 functions and to explore its roles in various developmental processes.
The development of Barhl1 inhibitors is rooted in the broader field of molecular biology and developmental biology, aiming to understand the intricate regulatory networks that govern neural development. These inhibitors are designed to selectively bind to Barhl1 and alter its interaction with DNA or other proteins, thereby affecting the expression of downstream target genes. Researchers utilize these inhibitors as tools for experimental purposes, dissecting the precise functions of Barhl1 in the context of embryogenesis and neural differentiation. By inhibiting Barhl1 activity, scientists can investigate the effects on neural cell fate determination and the molecular pathways influenced by this transcription factor, contributing to a deeper understanding of the complex processes that underlie embryonic development. It's important to note that Barhl1 inhibitors are primarily used as research reagents and are valuable for advancing our knowledge of gene regulation and neural development.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triclosan | 3380-34-5 | sc-220326 sc-220326A | 10 g 100 g | $141.00 $408.00 | ||
Triclosan inhibits the activity of enoyl-acyl carrier protein reductase (ENR), a key enzyme in the bacterial fatty acid synthesis pathway, ultimately suppressing Barhl1. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $26.00 $119.00 $213.00 | 27 | |
Inhibits tyrosine kinase activity, targeting BCR-ABL fusion protein in chronic myeloid leukemia. | ||||||
Sorafenib | 284461-73-0 | sc-220125 sc-220125A sc-220125B | 5 mg 50 mg 500 mg | $57.00 $100.00 $250.00 | 129 | |
Inhibits multiple kinases, including RAF kinase and VEGFR, in cancer. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Rotenone inhibits complex I of the mitochondrial electron transport chain, disrupting ATP synthesis and leading to cellular stress responses that down-regulate Barhl1 expression. | ||||||
Fomepizole | 7554-65-6 | sc-252838 | 1 g | $75.00 | 1 | |
Fomepizole inhibits alcohol dehydrogenase, leading to accumulation of toxic metabolites and activation of stress-responsive pathways that suppress Barhl1 expression. | ||||||
MDV3100 | 915087-33-1 | sc-364354 sc-364354A | 5 mg 50 mg | $245.00 $1051.00 | 7 | |
Acts as a competitive inhibitor of androgen receptor (AR) for prostate cancer. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Targets the epidermal growth factor receptor (EGFR) in non-small cell lung cancer. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB-203580 inhibits p38 MAPK, a key signaling molecule involved in stress response pathways, leading to down-regulation of Barhl1 expression through modulation of transcription factors. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin inhibits phosphatidylinositol 3-kinase (PI3K), disrupting downstream signaling cascades involved in cell survival and proliferation, ultimately suppressing Barhl1 expression. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Inhibits the proteasome, disrupting protein degradation and used in multiple myeloma therapy. | ||||||