p-HSP 27 Antibody (5B9): sc-81498
- p-HSP 27 Antibody (5B9) is a mouse monoclonal IgG2a, cited in 3 publications, provided at 50 µg/0.5 ml
- raised against phosphopeptide corresponding to amino acid residues surrounding serine 82 of HSP 27 of human origin
- recommended for detection of Ser 82 phosphorylated HSP 27 of mouse, rat, human and canine origin by WB and IP; non cross-reactive with non-phosphorylated HSP 27 or unrelated p-Ser proteins
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-HSP 27 Antibody (5B9). This work is in progress.
p-HSP 27 Antibody (5B9) is a mouse monoclonal IgG2a antibody that detects HSP 27 in mouse, rat, human, and canine samples through western blotting (WB) and immunoprecipitation (IP) applications. anti-HSP 27 antibody (5B9) specifically recognizes the phosphorylated form of HSP 27, which plays a crucial role in cellular stress responses and protects cells from damage during stressful conditions such as heat shock and oxidative stress. HSP 27 is predominantly located in the cytoplasm but translocates to the nucleus in response to stress, highlighting HSP 27′s importance in cellular signaling pathways that regulate survival and adaptation. Phosphorylation of HSP 27 at specific serine residues, particularly Ser 15, Ser 78, and Ser 82, is essential for function, as these modifications enhance chaperone activity and promote the formation of protein complexes that help in the refolding of denatured proteins. HSP 27′s ability to interact with various signaling molecules, including MAP kinase-activated protein kinase-2, underscores HSP 27′s significance in modulating cellular responses to stress and maintaining cellular homeostasis. With robust reactivity and specificity, HSP 27 monoclonal antibody (5B9) serves as an invaluable tool for researchers studying stress response mechanisms and heat shock protein roles in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-HSP 27 Antibody (5B9) | sc-81498 | 50 µg/0.5 ml | $322.00 |